Structure and Thermodynamics of Drug-RNA Aptamer Interactions

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4 - Da Costa et al 2013 Mini Rev Med Chem.pdf (900.57 KB)

Date

2013-03-01

Authors

Da Costa, Jason B.
Dieckmann, Thorsten

Advisor

Journal Title

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Volume Title

Publisher

Bentham Science Publishers

Abstract

This mini-review will provide an overview on the recent studies of structure and thermodynamics of RNA aptamers that target drug molecules. These aptamers are studied to provide insight into RNA drug interactions. This interaction is important due to the many roles RNA plays in cell biology.

Description

The published manuscript is available at EurekaSelect via http://www.eurekaselect.com/openurl/content.php?genre=article&doi=10.2174/1389557511313040001

Keywords

thermodynamics, Ribonucleic acid, aptamer, isothermal titration calorimetry, RNA structure, in vitro, PEG, AUCGCA loop

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Citation

URI

http://dx.doi.org/10.2174/1389557511313040001
 http://hdl.handle.net/10012/13233

Collections

Waterloo Research
Chemistry