dc.contributor.author | Lauritzen, Lotte | |
dc.contributor.author | Eriksen, S. E. | |
dc.contributor.author | Hjorth, Mads F. | |
dc.contributor.author | Nielsen, M. S. | |
dc.contributor.author | Olsen, Sjurdur F. | |
dc.contributor.author | Stark, Ken | |
dc.contributor.author | Michaelsen, Kim F. | |
dc.contributor.author | Damsgaard, Camilla T. | |
dc.date.accessioned | 2017-11-20 18:53:33 (GMT) | |
dc.date.available | 2017-11-20 18:53:33 (GMT) | |
dc.date.issued | 2016-12-28 | |
dc.identifier.uri | http:/dx.doi.org/10.1017/S0007114516004293 | |
dc.identifier.uri | http://hdl.handle.net/10012/12646 | |
dc.description | Published by Cambridge University Press in the British Journal of Nutrition. Lauritzen, L., Eriksen, S. E., Hjorth, M. F., Nielsen, M. S., Olsen, S. F., Stark, K. D., … Damsgaard, C. T. (2016). Maternal fish oil supplementation during lactation is associated with reduced height at 13 years of age and higher blood pressure in boys only. British Journal of Nutrition, 116(12), 2082–2090. https://doi.org/10.1017/S0007114516004293. This version is free to view and download for private research and study only. Not for re-distribution, re-sale or use in derivative works. © The Authors | en |
dc.description.abstract | Dietary long-chain n-3 PUFA (n-3 LCPUFA) in infancy may have long-term effects on lifestyle disease risk. The present follow-up study investigated whether maternal fish oil (FO) supplementation during lactation affected growth and blood pressure in adolescents and whether the effects differed between boys and girls. Mother-infant pairs (n 103) completed a randomised controlled trial with FO (1.5 g/d n-3 LCPUFA) or olive oil (OO) supplements during the first 4 months of lactation; forty-seven mother-infant pairs with high fish intake were followed-up for 4 months as the reference group. We also followed-up 100 children with assessment of growth, blood pressure, diet by FFQ and physical activity by 7-d accelerometry at 13.5 (SD 0.4) years of age. Dried whole-blood fatty acid composition was analysed in a subgroup (n 49). At 13 years of age, whole-blood n-3 LCPUFA, diet, physical activity and body composition did not differ between the three groups. The children from the FO group were 3.4 (95% CI 0.2, 6.6) cm shorter (P = 0.035) than those from the OO group, and tended to have less advanced puberty (P= 0.068), which explained the difference in height. There was a sex-specific effect on diastolic blood pressure (P-sex x group = 0.020), which was driven by a 3.9 (95% CI 0.2, 7.5) mmHg higher diastolic blood pressure in the FO compared with the OO group among boys only (P= 0.041). Our results indicate that early n-3 LCPUFA intake may reduce height in early adolescence due to a delay in pubertal maturation and increase blood pressure specifically in boys, thereby tending to counteract existing sex differences. | en |
dc.description.sponsorship | BASF Aktiengesellschaft | en |
dc.description.sponsorship | FOTEK, The Danish Research and Development Program for Food and Technology | en |
dc.language.iso | en | en |
dc.publisher | Cambridge University Press | en |
dc.subject | N-3 Long-Chain Pufa | en |
dc.subject | Puberty | en |
dc.subject | Growth | en |
dc.subject | Programming | en |
dc.subject | Health | en |
dc.title | Maternal fish oil supplementation during lactation is associated with reduced height at 13 years of age and higher blood pressure in boys only | en |
dc.type | Article | en |
dcterms.bibliographicCitation | Lauritzen, L., Eriksen, S. E., Hjorth, M. F., Nielsen, M. S., Olsen, S. F., Stark, K. D., … Damsgaard, C. T. (2016). Maternal fish oil supplementation during lactation is associated with reduced height at 13 years of age and higher blood pressure in boys only. British Journal of Nutrition, 116(12), 2082–2090. https://doi.org/10.1017/S0007114516004293 | en |
uws.contributor.affiliation1 | Faculty of Applied Health Sciences | en |
uws.contributor.affiliation2 | Kinesiology | en |
uws.typeOfResource | Text | en |
uws.peerReviewStatus | Reviewed | en |
uws.scholarLevel | Faculty | en |