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dc.contributor.authorYinko, Sylvie S. L. Leung
dc.contributor.authorPelletier, Roxanne
dc.contributor.authorBehlouli, Hassan
dc.contributor.authorNorris, Colleen M.
dc.contributor.authorHumphries, Karin H.
dc.contributor.authorPilote, Louise 18:53:28 (GMT) 18:53:28 (GMT)
dc.description.abstractBackground-Limited data exist as to the relative contribution of sex and gender on health-related quality of life (HRQL) among patients with acute coronary syndrome (ACS). This study aims to evaluate the effect of sex and gender-related variables on long-term HRQL among young adults with ACS. Methods and Results-GENESIS-PRAXY (GENdEr and Sex determInantS of cardiovascular disease: from bench to beyond-Premature Acute Coronary SYndrome) is a multicenter, prospective cohort study (January 2009 to August 2013) of adults aged 18 to 55 years, hospitalized with ACS. HRQL was measured at baseline, 1, 6, and 12 months using the Short Form-12 and Seattle Angina Questionnaire (SAQ) among 1213 patients. Median age was 49 years. Women reported worse HRQL than men over time post-ACS, both in terms of physical and mental functioning. Gender-related factors were more likely to be predictors of HRQL than sex. Femininity score, social support, and housework responsibility were the most common gender-related predictors of HRQL at 12 months. We observed an interaction between female sex and social support (beta=0.44 [95% confidence interval, 0.01, 0.88]; P=0.047) for the physical limitation subscale of the SAQ. Conclusions-Young women with ACS report significantly poorer HRQL than young men. Gender appears to be more important than sex in predicting long-term HRQL post-ACS. Specific gender-related factors, such as social support, may be amenable to interventions and could improve the HRQL of patients with premature ACS.en
dc.description.sponsorshipHeart and Stroke Foundation of Quebecen
dc.description.sponsorshipHeart and Stroke Foundation of Nova Scotiaen
dc.description.sponsorshipHeart and Stroke Foundation of Albertaen
dc.description.sponsorshipHeart and Stroke Foundation of Ontarioen
dc.description.sponsorshipHeart and Stroke Foundation of Yukonen
dc.description.sponsorshipHeart and Stroke Foundation of British Columbia, Canadaen
dc.description.sponsorshipJames McGill Chair at McGill Universityen
dc.rightsAttribution 3.0 Unported*
dc.subjectCardiovascular Diseasesen
dc.subjectMyocardial Infarctionen
dc.titleHealth-Related Quality of Life in Premature Acute Coronary Syndrome: Does Patient Sex or Gender Really Matter?en
dcterms.bibliographicCitationLeung Yinko, S. S. L., Pelletier, R., Behlouli, H., Norris, C. M., Humphries, K. H., Pilote, L., & the GENESIS-PRAXY investigators. (2014). Health-Related Quality of Life in Premature Acute Coronary Syndrome: Does Patient Sex or Gender Really Matter? Journal of the American Heart Association, 3(4), e000901–e000901.
uws.contributor.affiliation1Faculty of Applied Health Sciencesen

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