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dc.contributor.authorVendelbo Lind, Mads
dc.contributor.authorLauritzen, Lotte
dc.contributor.authorPedersen, Oluf
dc.contributor.authorVestergaard, Henrik
dc.contributor.authorStark, Ken
dc.contributor.authorHansen, Torben
dc.contributor.authorRoss, Alastair B.
dc.contributor.authorKristensen, Mette
dc.date.accessioned2017-11-17 15:04:54 (GMT)
dc.date.available2017-11-17 15:04:54 (GMT)
dc.date.issued2017-10-02
dc.identifier.urihttps://doi.org/10.1016/j.nutres.2017.09.008
dc.identifier.urihttp://hdl.handle.net/10012/12636
dc.descriptionThe final publication is available at Elsevier via https://doi.org/10.1016/j.nutres.2017.09.008 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.description.abstractSeveral B-vitamins act as co-factors in one-carbon metabolism, a pathway that plays a central role in several chronic diseases. However, there is a lack of knowledge of how diet affects markers in one-carbon metabolism. The aim of this study was to explore dietary patterns and components associated with one-carbon metabolites. We hypothesized that intake of whole-grains and fish would be associated with lower Hcy, and higher SAM:SAH ratio due to their nutrient content. We assessed dietary information using a four-day dietary record in 118 men and women with features of the metabolic syndrome. In addition we assessed whole-blood fatty acid composition and plasma alkylresorcinols. Plasma s-adenosylmethionine (SAM), s-adenosylhomocysteine (SAH), homocysteine (Hcy) and vitamin B12 was included as one-carbon metabolism markers. We used principal component analysis (PCA) to explore dietary patterns and multiple linear regression models to examine associations between dietary factors and one-carbon metabolites. PCA separated subjects based on prudent and unhealthy dietary patterns, but the dietary pattern score was not related to the one-carbon metabolites. Whole grain intake was found to be inversely associated to plasma Hcy (?4.7% (?9.3; 0.0), P=.05) and total grain intake tended to be positively associated with SAM and SAH (2.4% (?0.5; 5.5), P=.08; 5.8% (?0.2; 12.1), P=.06, respectively, per SD increase in cereal intake). Fish intake was inversely associated with plasma Hcy and SAH concentrations (?5.4% (?9.7; ?0.8), P=.02 and ?7.0% (?12.1; ?1.5), P=.01, respectively) and positively associated with the SAM:SAH ratio (6.2% (1.6; 11.0), P=.008). In conclusion, intake and fish and whole-grain appear to be associated with a beneficial one-carbon metabolism profile. This indicates that dietary components could play a role in regulation of one-carbon metabolism with a potential impact on disease prevention.en
dc.description.sponsorshipInnovation Fund Denmark, grant no. 0603-00487B (11-116163). MV Lind partly supported by an unrestricted grant from Cereal Partners Worldwide a joint venture between Nestlé SA and General Mills Ltd.en
dc.language.isoenen
dc.publisherElsevieren
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectDietary patternsen
dc.subjectHomocysteineen
dc.subjectLong-chain polyunsaturated fatty acidsen
dc.subjectMethyl donor metabolismen
dc.subjectWhole grainen
dc.titleHigher intake of fish and fat is associated with lower plasma s-adenosylhomocysteine: a cross-sectional studyen
dc.typeArticleen
dcterms.bibliographicCitationLind, M. V., Lauritzen, L., Pedersen, O., Vestergaard, H., Stark, K. D., Hansen, T., … Kristensen, M. (2017). Higher intake of fish and fat is associated with lower plasma s-adenosylhomocysteine: a cross-sectional study. Nutrition Research. https://doi.org/10.1016/j.nutres.2017.09.008en
uws.contributor.affiliation1Faculty of Applied Health Sciencesen
uws.contributor.affiliation2Kinesiologyen
uws.typeOfResourceTexten
uws.peerReviewStatusRevieweden
uws.scholarLevelFacultyen


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