Show simple item record

dc.contributor.authorWang, Feng
dc.contributor.authorZhang, Xiaohan
dc.contributor.authorLiu, Yibo
dc.contributor.authorLin, Zhi Yuan (William)
dc.contributor.authorLiu, Biwu
dc.contributor.authorLiu, Juewen
dc.date.accessioned2017-04-28 16:12:06 (GMT)
dc.date.available2017-04-28 16:12:06 (GMT)
dc.date.issued2016-09-19
dc.identifier.urihttp://dx.doi.org/10.1002/anie.201606603
dc.identifier.urihttp://hdl.handle.net/10012/11810
dc.descriptionThis is the peer reviewed version of the following article: Wang, F., Zhang, X., Liu, Y., Lin, Z. Y., Liu, B., & Liu, J. (2016). Profiling Metal Oxides with Lipids: Magnetic Liposomal Nanoparticles Displaying DNA and Proteins. Angewandte Chemie-International Edition, 55(39), 12063–12067, which has been published in final form at https://doi.org/10.1002/anie.201606603. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.en
dc.description.abstractMetal oxides include many important materials with various surface properties. For biomedical and analytical applications, it is desirable to engineer their biocompatible interfaces. Herein, a phosphocholine liposome (DOPC) and its headgroup dipole flipped counterpart (DOCP) were mixed with ten common oxides. Using the calcein leakage assay, cryo-TEM, and z-potential measurement, these oxides were grouped into three types. The type 1 oxides (Fe3O4, TiO2, ZrO2, Y2O3, ITO, In2O3, and Mn2O3) form supported bilayers only with DOCP. Type 2 (SiO2) forms supported bilayers only with DOPC; type 3 (ZnO and NiO) are cationic and damage lipid membranes. Magnetic Fe3O4 nanoparticles were further studied for conjugation of fluorophores, proteins, and DNA to the supported DOCP bilayers via lipid headgroup labeling, covalent linking, or lipid insertion. Delivery of the conjugates to cells and selective DNA hybridization were demonstrated. This work provides a general solution for coating the type 1 oxides with a simple mixing in water, facilitating applications in biosensing, separation, and nanomedicine.en
dc.description.sponsorshipNatural Sciences and Engineering Research Council of Canada (NSERC); National Natural Science Foundation of China [31571023, 81501587]; Hefei University of Technologyen
dc.language.isoenen
dc.publisherWileyen
dc.subjectSilica Nanoparticlesen
dc.subjectZero Chargeen
dc.subjectBilayersen
dc.subjectFunctionalizationen
dc.subjectDeliveryen
dc.subjectMembranesen
dc.subjectMrien
dc.subjectPhosphocholineen
dc.subjectSizeen
dc.titleProfiling Metal Oxides with Lipids: Magnetic Liposomal Nanoparticles Displaying DNA and Proteinsen
dc.typeArticleen
dcterms.bibliographicCitationWang, F., Zhang, X., Liu, Y., Lin, Z. Y., Liu, B., & Liu, J. (2016). Profiling Metal Oxides with Lipids: Magnetic Liposomal Nanoparticles Displaying DNA and Proteins. Angewandte Chemie-International Edition, 55(39), 12063–12067. https://doi.org/10.1002/anie.201606603en
uws.contributor.affiliation1Faculty of Scienceen
uws.contributor.affiliation2Chemistryen
uws.contributor.affiliation3Waterloo Institute for Nanotechnology (WIN)en
uws.typeOfResourceTexten
uws.peerReviewStatusRevieweden
uws.scholarLevelFacultyen


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record


UWSpace

University of Waterloo Library
200 University Avenue West
Waterloo, Ontario, Canada N2L 3G1
519 888 4883

All items in UWSpace are protected by copyright, with all rights reserved.

DSpace software

Service outages