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Synergistic pH effect for reversible shuttling aptamer-based biosensors between graphene oxide and target molecules

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Liu_Juewen(9).pdf (442.19 KB)

Date

2011-06-07

Authors

Huang, Po-Jung Jimmy
Kempaiah, Ravindra
Liu, Juewen

Journal Title

Journal ISSN

Volume Title

Publisher

Royal Society of Chemistry

Abstract

DNA aptamers are known to desorb from graphene oxide (GO) surface in the presence of target molecules. We demonstrate herein that the binding equilibrium can be shifted by simply tuning the solution pH. At lower pH, the aptamer/GO binding is enhanced while aptamer/target binding is weakened, making this system a regenerable biosensor without covalent conjugation.

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Keywords

pH, biosensors, graphene oxide, DNA

LC Keywords

Citation

URI

http://dx.doi.org/10.1039/C1JM11702E
 http://hdl.handle.net/10012/11541

Collections

Waterloo Research
Chemistry
Waterloo Institute for Nanotechnology