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dc.contributor.authorEl-Hamed, Firas
dc.contributor.authorDave, Neeshma
dc.contributor.authorLiu, Juewen
dc.date.accessioned2017-03-16 14:46:10 (GMT)
dc.date.available2017-03-16 14:46:10 (GMT)
dc.date.issued2011-11-21
dc.identifier.urihttp://dx.doi.org/10.1088/0957-4484/22/49/494011
dc.identifier.urihttp://hdl.handle.net/10012/11502
dc.descriptionThis is an author-created, un-copyedited version of an article accepted for publication/published in Nanotechnology. IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The Version of Record is available online at https://doi.org/10.1088/0957-4484/22/49/494011en
dc.description.abstractControlled release of therapeutic agents is important for improving drug efficacy and reducing toxicity. Recently, hydrogels have been used for controlled release applications. While the majority of the previous work focused on releasing the cargo in response to physical stimuli such as temperature, light, electric field, and pH, we aim to trigger cargo release in the presence of small metabolites. In our system a DNA aptamer that can bind to adenosine, AMP, and ATP was used as a linker to attach either DNA-functionalized gold nanoparticles or liposomes to DNA-functionalized hydrogels. In the presence of the metabolite, both the nanoparticle and liposome cargos were released. The effect of salt, temperature, target concentration, and drying has been systematically studied. Interestingly, we found that the gel can be completely dried while retaining the DNA linkages and adenosine induced release was still achieved after rehydration. Our work demonstrates that aptamers can be used to control the release of drugs and other materials attached to hydrogels.en
dc.description.sponsorshipUniversity of Waterloo || Canadian Foundation for Innovation || Natural Sciences and Engineering Research Council ||en
dc.language.isoenen
dc.publisherInstitute of Physicsen
dc.subjectDNAen
dc.subjectAptamersen
dc.subjectGold nanoparticlesen
dc.subjectLiposomesen
dc.subjectHydrogelsen
dc.titleStimuli-responsive releasing of gold nanoparticles and liposomes from aptamer-functionalized hydrogelsen
dc.typeArticleen
dcterms.bibliographicCitationEl-Hamed, F., Dave, N., & Liu, J. (2011). Stimuli-responsive releasing of gold nanoparticles and liposomes from aptamer-functionalized hydrogels. Nanotechnology, 22(49), 494011.en
uws.contributor.affiliation1Faculty of Scienceen
uws.contributor.affiliation2Chemistryen
uws.contributor.affiliation2Waterloo Institute for Nanotechnology (WIN)en
uws.typeOfResourceTexten
uws.peerReviewStatusRevieweden
uws.scholarLevelFacultyen


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