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dc.contributor.authorHui, Alex
dc.contributor.authorWillcox, Mark D. P.
dc.contributor.authorJones, Lyndon W.
dc.date.accessioned2017-03-07 19:47:57 (GMT)
dc.date.available2017-03-07 19:47:57 (GMT)
dc.date.issued2014-08-08
dc.identifier.urihttp://hdl.handle.net/10012/11459
dc.identifier.urihttp://dx.doi.org/10.1167/iovs.14-14855
dc.descriptionHui, A., Willcox, M., & Jones, L. (2014). In Vitro and In Vivo Evaluation of Novel Ciprofloxacin-Releasing Silicone Hydrogel Contact Lenses. Investigative Opthalmology & Visual Science, 55(8), 4896. https://doi.org/10.1167/iovs.14-14855en
dc.description.abstractPurpose.: The purpose of this study was to evaluate ciprofloxacin-releasing silicone hydrogel contact lens materials in vitro and in vivo for the treatment of microbial keratitis. Methods.: Model silicone hydrogel contact lens materials were manufactured using a molecular imprinting technique to modify ciprofloxacin release kinetics. Various contact lens properties, including light transmission and surface wettability, were determined, and the in vitro ciprofloxacin release kinetics elucidated using fluorescence spectrophotometry. The materials then were evaluated for their ability to inhibit Pseudomonas aeruginosa growth in vitro and in an in vivo rabbit model of microbial keratitis. Results.: Synthesized lenses had similar material properties to commercial contact lens materials. There was a decrease in light transmission in the shorter wavelengths due to incorporation of the antibiotic, but over 80% light transmission between 400 and 700 nm. Modified materials released for more than 8 hours, significantly longer than unmodified controls (P < 0.05). In vivo, there was no statistically significant difference between the number of colony-forming units (CFU) recovered from corneas treated with eye drops and those treated with one of two modified contact lenses (P > 0.05), which is significantly less than corneas treated with unmodified control lenses or those that received no treatment at all (P < 0.05). Conclusions.: These novel contact lenses designed for the extended release of ciprofloxacin may be beneficial to supplement or augment future treatments of sight-threatening microbial keratitis.en
dc.description.sponsorshipSupported by the Natural Science and Engineering Research Council of Canada (NSERC)
dc.description.sponsorship20/20 Network for the Development of Advanced Ophthalmic Materials
dc.description.sponsorshipand by an NSERC Alexander Graham Bell Doctoral Scholarship
dc.description.sponsorshipthe Ezell Fellowship from the American Optometric Foundation
dc.description.sponsorshipand the Endeavour Research Grant from the Australian Government (AH).
dc.language.isoenen
dc.publisherAssociation for Research in Vision and Ophthalmologyen
dc.rightsAttribution 4.0 International*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectContact lensen
dc.subjectMicrobial keratitisen
dc.subjectDrug deliveryen
dc.subjectMolecular imprintingen
dc.subjectCiprofloxacinen
dc.titleIn Vitro and In Vivo Evaluation of Novel Ciprofloxacin-Releasing Silicone Hydrogel Contact Lensesen
dc.typeArticleen
dcterms.bibliographicCitationHui, A., Willcox, M., & Jones, L. (2014). In Vitro and In Vivo Evaluation of Novel Ciprofloxacin-Releasing Silicone Hydrogel Contact Lenses. Investigative Opthalmology & Visual Science, 55(8), 4896. https://doi.org/10.1167/iovs.14-14855en
uws.contributor.affiliation1Faculty of Scienceen
uws.contributor.affiliation2School of Optometry and Vision Scienceen
uws.typeOfResourceTexten
uws.peerReviewStatusRevieweden
uws.scholarLevelFacultyen


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