dc.contributor.author | Menzies, K. L. | |
dc.contributor.author | Srinivasan, Sruthi | |
dc.contributor.author | Prokopich, C. L. | |
dc.contributor.author | Jones, Lyndon W. | |
dc.date.accessioned | 2017-03-07 19:47:54 (GMT) | |
dc.date.available | 2017-03-07 19:47:54 (GMT) | |
dc.date.issued | 2015-05-02 | |
dc.identifier.uri | http://dx.doi.org/10.1167/iovs.14-13864 | |
dc.identifier.uri | http://hdl.handle.net/10012/11450 | |
dc.description | Menzies, K. L., Srinivasan, S., Prokopich, C. L., & Jones, L. (2015). Infrared Imaging of Meibomian Glands and Evaluation of the Lipid Layer in Sjogren’s Syndrome Patients and Nondry Eye Controls. Investigative Ophthalmology & Visual Science, 56(2), 836–841. https://doi.org/10.1167/iovs.14-13864 | en |
dc.description.abstract | Purpose.: The purpose of this study was to evaluate meibomian gland dropout and lipid layer thickness (LLT) in patients with and without Sjögren's syndrome dry eye (SS). Methods.: We recruited 11 participants with SS (males/females [M/F], 1:10; mean age = 56.0 ± 9.1 years) and 10 control subjects without dry eye (M/F, 3:7; mean age = 58.5 ± 4.7 years). All participants completed the Ocular Surface Disease Index (OSDI) questionnaire. The LLT was assessed using the Tearscope Plus based on the appearance of the lipid layer. Noninvasive tear break-up time (NITBUT) also was measured. The lower and upper lids were everted, and the meibomian glands were imaged using the infrared camera of the Keratograph 4. A meibomian gland dropout score due to gland loss was obtained. Statistical analysis was conducted using the Mann-Whitney U test and correlations were determined using Spearman rank correlations. Results.: Of the SS participants, 100% reported ocular and oral dryness symptoms in the AECC questionnaire. The SS group recorded a higher OSDI score (median = 48.00, interquartile range [IQR] 23.0–56.2 vs. 2.1, IQR 0.0–2.6; P < 0.001), reduced LLT (median [IQR] = 15.0 [15.0–15.0] vs. 60.0 [45.0–100.0] nm; P = 0.001), and lower NITBUT (median [IQR] = 3.7 [2.5–4.2] vs. 9.5 [6.4–17.6] sec; P < 0.001) compared to the controls. Digital meibomian gland dropout score (% dropout) was significantly higher for the SS group (16.0% [IQR 12.1–40.0%] vs. 6.7% [IQR 1.5–12.7%]; P = 0.01). Subjective meibomian gland dropout score (0–6 score) was significantly higher for the SS group (median [IQR] = 1.5 [1.0–4.0] vs. 1.0 [0.0–1.25]; P = 0.03). Conclusions.: Patients with SS showed higher meibomian gland dropout scores and reduced LLT and NITBUT, which likely contribute to the severe dry eye symptoms reported by SS subjects. | en |
dc.language.iso | en | en |
dc.publisher | Association for Research in Vision and Ophthalmology | en |
dc.rights | Attribution 4.0 International | * |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Sjögren’s syndrome | en |
dc.subject | meibography | en |
dc.subject | tear breakup time | en |
dc.subject | lipid layer | en |
dc.subject | dry eye | en |
dc.subject | MGD | en |
dc.title | Infrared Imaging of Meibomian Glands and Evaluation of the Lipid Layer in Sjogren's Syndrome Patients and Nondry Eye Controls | en |
dc.type | Article | en |
dcterms.bibliographicCitation | Menzies, K. L., Srinivasan, S., Prokopich, C. L., & Jones, L. (2015). Infrared Imaging of Meibomian Glands and Evaluation of the Lipid Layer in Sjogren’s Syndrome Patients and Nondry Eye Controls. Investigative Ophthalmology & Visual Science, 56(2), 836–841. https://doi.org/10.1167/iovs.14-13864 | en |
uws.contributor.affiliation1 | Faculty of Science | en |
uws.contributor.affiliation2 | School of Optometry and Vision Science | en |
uws.typeOfResource | Text | en |
uws.peerReviewStatus | Reviewed | en |
uws.scholarLevel | Faculty | en |