Show simple item record

dc.contributor.authorPhan, Chau-Minh
dc.contributor.authorWalther, Hendrik
dc.contributor.authorGao, Huayi
dc.contributor.authorRossy, Jordan
dc.contributor.authorSubbaraman, Lakshman N.
dc.contributor.authorJones, Lyndon W. 19:47:52 (GMT) 19:47:52 (GMT)
dc.descriptionThe definitive version of Development of an in Vitro Ocular Platform to Test Contact Lenses was published by Emerald in Journal of Visualized Experiments, (110) (2016)
dc.description.abstractCurrently, in vitro evaluations of contact lenses (CLs) for drug delivery are typically performed in large volume vials,1-6 which fail to mimic physiological tear volumes.7 The traditional model also lacks the natural tear flow component and the blinking reflex, both of which are defining factors of the ocular environment. The development of a novel model is described in this study, which consists of a unique 2-piece design, eyeball and eyelid piece, capable of mimicking physiological tear volume. The models are created from 3-D printed molds (Polytetrafluoroethylene or Teflon molds), which can be used to generate eye models from various polymers, such as polydimethylsiloxane (PDMS) and agar. Further modifications to the eye pieces, such as the integration of an explanted human or animal cornea or human corneal construct, will permit for more complex in vitro ocular studies. A commercial microfluidic syringe pump is integrated with the platform to emulate physiological tear secretion. Air exposure and mechanical wear are achieved using two mechanical actuators, of which one moves the eyelid piece laterally, and the other moves the eyeballeyepiece circularly. The model has been used to evaluate CLs for drug delivery and deposition of tear components on CLs.en
dc.publisherJournal of Visualized Experimentsen
dc.subjectIssue 110en
dc.subjectEye modelen
dc.subjectIn vitroen
dc.subjectContact lensesen
dc.subjectTear depositionen
dc.subjectDrug deliveryen
dc.subjectAgar modelen
dc.subjectOphthalmic materialsen
dc.subjectEx vivo corneaen
dc.titleDevelopment of an In Vitro Ocular Platform to Test Contact Lensesen
dcterms.bibliographicCitationPhan, C.-M., Walther, H., Gao, H., Rossy, J., Subbaraman, L. N., & Jones, L. (2016). Development of an in Vitro Ocular Platform to Test Contact Lenses. Journal of Visualized Experiments, (110).
uws.contributor.affiliation1Faculty of Scienceen
uws.contributor.affiliation2School of Optometry and Vision Scienceen

Files in this item


This item appears in the following Collection(s)

Show simple item record


University of Waterloo Library
200 University Avenue West
Waterloo, Ontario, Canada N2L 3G1
519 888 4883

All items in UWSpace are protected by copyright, with all rights reserved.

DSpace software

Service outages