Ultrahigh Nanoparticle Stability against Salt, pH, and Solvent with Retained Surface Accessibility via Depletion Stabilization
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Date
2012-06-20
Authors
Zhang, Xu
Servos, Mark R.
Liu, Juewen
Journal Title
Journal ISSN
Volume Title
Publisher
American Chemical Society
Abstract
For many applications, it is desirable to stabilize colloids over a wide range of buffer conditions while still retaining surface accessibility for adsorption and reaction. Commonly used charge or steric stabilization cannot achieve this goal since the former is sensitive to salt and the latter blocks the particle surface. We use depletion stabilization in the presence of high molecular weight polyethylene glycol (PEG) to stabilize a diverse range of nanomaterials, including gold nanoparticles (from 10 to 100 nm), graphene oxide, quantum dots, silica nanoparticles, and liposomes in the presence of Mg2+ (>1.6 M), heavy metal ions, extreme pH (pH 1–13), organic solvents, and adsorbed nucleosides and drugs. At the same time, the particle surface remains accessible for adsorption of both small molecules and macromolecules. Based on this study, high loading of thiolated DNA was achieved in one step with just 2% PEG 20 000 in 2 h.
Description
This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of the American Chemistry Society copyright © American Chemical Society after peer review and technical editing by publisher. To access the final edited and published work see Zhang, X., Servos, M. R., & Liu, J. (2012). Ultrahigh Nanoparticle Stability against Salt, pH, and Solvent with Retained Surface Accessibility via Depletion Stabilization. Journal of the American Chemical Society, 134(24), 9910–9913. https://doi.org/10.1021/ja303787e
Keywords
nanoparticle, DNA, pH, salt, solvent