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dc.contributor.authorMateron, Elsa M.
dc.contributor.authorHuang, Po-Jung Jimmy
dc.contributor.authorWong, Ademar
dc.contributor.authorFerreira, Antonio A. Pupim
dc.contributor.authorSotomayor, Maria Del Pilar Taboada
dc.contributor.authorLiu, Juewen 20:01:30 (GMT) 20:01:30 (GMT)
dc.descriptionThe final publication is available at Elsevier via © 2014. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
dc.description.abstractWith the fast growth of cancer research, new analytical methods are needed to measure anticancer drugs. This is usually accomplished by using sophisticated analytical instruments. Biosensors are attractive candidates for measuring anticancer drugs, but currently few biosensors can achieve this goal. In particular, it is challenging to have a general method to monitor various types of anticancer drugs with different structures. In this work, a biosensor was developed to detect anticancer drugs by modifying carbon paste electrodes with glutathione-s-transferase (GST) enzymes. GST is widely studied in the metabolism of xenobiotics and is a major contributing factor in resistance to anticancer drugs. The measurement of anticancer drugs is based on competition between 1-chloro-2,4-dinitrobenzene (CDNB) and the drugs for the GST enzyme in the electrochemical potential at 0.1 V vs. Ag/AgCl by square wave voltammetry (SWV) or using a colorimetric method. The sensor shows a detection limit of 8.8 μM cisplatin and exhibits relatively long life time in daily measurements.en
dc.description.sponsorshipUniversity of Waterloo || Natural Sciences and Engineering Research Council || Emerging Leaders in the Americas Program ||en
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.subjectCarbon past electrodeen
dc.titleGlutathione-s-transferase modified electrodes for detecting anticancer drugsen
dcterms.bibliographicCitationMateron, E. M., Jimmy Huang, P.-J., Wong, A., Pupim Ferreira, A. A., Sotomayor, M. D. P. T., & Liu, J. (2014). Glutathione-s-transferase modified electrodes for detecting anticancer drugs. Biosensors and Bioelectronics, 58, 232–236.
uws.contributor.affiliation1Faculty of Scienceen
uws.contributor.affiliation2Waterloo Institute for Nanotechnology (WIN)en

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