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dc.contributor.authorWang, Feng
dc.contributor.authorLiu, Juewen
dc.date.accessioned2017-02-24 19:36:47 (GMT)
dc.date.available2017-02-24 19:36:47 (GMT)
dc.date.issued2015-10-14
dc.identifier.urihttp://dx.doi.org/10.1039/C5NR04805B
dc.identifier.urihttp://hdl.handle.net/10012/11354
dc.description.abstractWe herein report that the adsorption/desorption of citrate-capped gold nanoparticles (AuNPs) transiently causes leakage in fluid phase DOPC liposomes, while the liposomes do not leak with AuNPs capped with mercaptopropionic acid (MPA). Leakage also fails to occur for gel phase DPPC liposomes. Citrate-capped (but not MPA-capped) AuNPs raise the phase transition temperature of DPPC. We conclude that citrate-capped AuNPs interact with the PC liposomes very strongly, inducing a local fluid-to-gel lipid phase transition for DOPC. Leakage takes place during this transition, and the membrane integrity is resumed after the transition. Citrate-capped AuNPs allow stronger van der Waals forces than MPA-capped AuNPs with PC liposomes, since the latter are separated from the liposome surface by the ∼0.3 nm MPA layer.en
dc.description.sponsorshipUniversity of Waterloo || Canadian Foundation for Innovation || Ontario Ministry of Research and Innovation ||en
dc.language.isoenen
dc.publisherRoyal Society of Chemistryen
dc.subjectgold nanoparticlesen
dc.subjectliposomeen
dc.subjectadsorptionen
dc.subjectdesorptionen
dc.subjectlipid phase transitionen
dc.titleSelf-healable and reversible liposome leakage by citrate-capped gold nanoparticles probing initial adsorption/desorption induced lipid phase transitionen
dc.typeArticleen
dcterms.bibliographicCitationWang, F., & Liu, J. (2015). Self-healable and reversible liposome leakage by citrate-capped gold nanoparticles: probing the initial adsorption/desorption induced lipid phase transition. Nanoscale, 7(38), 15599–15604. https://doi.org/10.1039/C5NR04805Ben
uws.contributor.affiliation1Faculty of Scienceen
uws.contributor.affiliation2Chemistryen
uws.contributor.affiliation2Waterloo Institute for Nanotechnology (WIN)en
uws.typeOfResourceTexten
uws.peerReviewStatusRevieweden
uws.scholarLevelFacultyen


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