Browsing University of Waterloo by Supervisor "Yim, Evelyn"
Now showing items 1-12 of 12
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Biointerface Topography for Enhanced Nonviral Gene Delivery
(University of Waterloo, 2023-12-11)Substrate-mediated nonviral gene delivery (SMD) represents a burgeoning area of interest in the field of tissue engineering due to its potential to facilitate localized transfection while providing the scaffolding for ... -
Biophysical cues to enhance neuronal differentiation
(University of Waterloo, 2021-05-31)Biophysical cues are an important tool for neuronal tissue engineering and regenerative medicine. Cues such as topography and stiffness have been shown to enhance lineage and non-lineage based neuronal differentiation by ... -
Corneal epithelial cell responses to tensile stress and compressive stress
(University of Waterloo, 2020-11-03)Eye rubbing is a commonly adopted habit that is frequently happening in our daily life. However, the mechanical stress generated by long term chronic abnormal eye rubbing could lead to keratoconus (KC) with the symptoms ... -
A Droplet Microfluidic Platform Used to Encapsulate Single Pre-formed Cancer Spheroids in Hydrogel Microenvironments
(University of Waterloo, 2024-04-19)Cancer has been a leading cause of death around the world for many years. Even with the emerging technologies seen in these times, there is still a lack of truly personalized treatments since cancer tumors are not fully ... -
Effect of Topography, Stiffness and Biochemicals on Neuronal Differentiation
(University of Waterloo, 2022-02-18)The mechanical and biochemical modifications of the hydrogel substrates play an essential role in tissue engineering research and neurodegenerative therapies. Topography, stiffness, and biochemicals are known to have ... -
Endothelialisation of Polyvinyl Alcohol Small Diameter Vascular Graft
(University of Waterloo, 2018-04-30)As one of the possible treatments for cardiovascular disease (CVD), bypass grafting in small diameter vessel (≤ 6 mm diameter) is often employed. However, maintaining the patency of this small diameter graft remains a ... -
Exploring the Cytoskeleton and Apoptosis Mechanisms in Fuchs Endothelial Corneal Dystrophy Using In Vitro Biomimetic Models and Immortalized FECD Cells
(University of Waterloo, 2023-12-14)Fuchs endothelial corneal dystrophy (FECD) is a corneal endothelium (CE) and Descemet’s membrane (DM) dysfunction symptom, which is the most common corneal endothelial disease. Despite the long history of clinical assessments ... -
Gelatin Methacrylate as a Controlled Release Vehicle for Treatment of Recurrent Corneal Erosion
(University of Waterloo, 2018-09-04)Patients with recurrent corneal erosions (RCE) experience unpredictable and painful episodes, caused by the loss of superficial corneal epithelial cells. The erratic nature of RCE often leads to patient anxiety, and can ... -
In vitro model for Fuchs Endothelial Dystrophy and its effects on corneal endothelial cells
(University of Waterloo, 2020-05-22)Fuchs endothelial dystrophy (FED), a corneal endothelium disease, is one of the leading causes for corneal transplantation. During disease progression, Descemet membrane’s (DM), the corneal endothelial basement membrane, ... -
Micro- and Nano-Topographies to Enhance Non-viral Transfection and Non-viral Neuronal Transdifferentiation of hMSCs
(University of Waterloo, 2018-09-26)Transfection and direct conversion, which is referred to as “transdifferentiation” in this thesis, play significant roles in regenerative medicine research including gene therapy, vaccines, modeling of diseases and disorders, ... -
Modification of poly(vinyl alcohol) hydrogels for small diameter vascular graft application
(University of Waterloo, 2021-08-16)Vascular disease remains the leading cause of death globally. Bypass grafting is one of the common surgical interventions to restore the blood flow. Autologous grafts, especially internal thoracic arteries and saphenous ... -
Physical patterning of silicone hydrogel to alter surface wettability, tear lipid deposition and bacterial adhesion
(University of Waterloo, 2021-12-20)A hydrogel is defined as a three-dimensional network of polymer chains that can swell and retain a significant fraction of water inside its structure without dissolving in water. Outstanding properties of a hydrogel such ...