Browsing University of Waterloo by Subject "physiology"
Now showing items 1-9 of 9
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Aging affects circadian clock and metabolism and modulates timing of medication
(Elsevier, 2021-04)Aging is associated with impairments in the circadian rhythms, and with energy deregulation that affects multiple metabolic pathways. The goal of this study is to unravel the complex interactions among aging, metabolism, ... -
Aspects of Corneal Fluorescein Staining
(University of Waterloo, 2019-04-25)PURPOSE Evaluating the cornea for epithelial fluorescein staining is a key element of the ocular examination of contact lens wearers and people with dry eye disease. It has long been viewed as a method of visualizing a ... -
Impact of sex and pathophysiology on optimal drug choice in hypertensive rats: Quantitative insights for precision medicine
(Elsevier, 2021-04)Less than half of all hypertensive patients receiving treatment are successful in normalizing their blood pressure. Despite the complexity and heterogeneity of hypertension, the current antihypertensive guidelines are not ... -
Investigating the role of task intensity on motor unit fatigue recovery
(University of Waterloo, 2023-01-05)Background: It is unclear how the intensity as well as the underlying contributions of larger versus smaller motor units of a performed task impacts fatigue recovery. Therefore, I tested two hypotheses: that the normalized ... -
Mathematical Modeling of Kidney Function During Pregnancy
(University of Waterloo, 2022-05-16)During pregnancy major adaptations must occur in the maternal body to be able to support the rapidly developing fetus and placenta. Adaptations occur in almost all tissues and organs. These changes are dynamic, complex, ... -
Physiological demands and ventilatory requirements during simulated large structure firefighting tasks
(University of Waterloo, 2007-09-25)The ability to measure the physiological demands and air requirements during simulated firefighting tasks while wearing full personal protective ensemble (PPE) and positive pressure self-contained breathing apparatus (SCBA) ... -
The physiological ecology of preparing for and recovering from hibernation in temperate insectivorous bats
(University of Waterloo, 2023-01-12)Temperate insectivorous bats that hibernate must both prepare for and recover from hibernation during times of the year with low resource abundance and low ambient temperatures, resulting in energetic bottlenecks in both ... -
Physiologically Based Pharmacokinetic Modeling of Monoclonal Antibodies in Children
(University of Waterloo, 2021-06-25)The following thesis chapters chronicle evolving efforts throughout 2016 – 2021 to support research toward improving the pediatric clinical pharmacology of monoclonal antibodies (mAbs). Translating the benefits of successful ... -
Supramaximal Testing to Confirm the Achievement of V̇O2max in Acute Hypoxia
(University of Waterloo, 2023-01-23)Incremental exercise tests are often used to quantify an individual’s maximal oxygen uptake (V̇O2max). To confirm V̇O2max, a bout of supramaximal exercise can be performed after maximal exercise and if V̇O2 is within the ...