Glucopsychosine increases cytosolic calcium to induce calpain-mediated apoptosis of acute myeloid leukemia cells.

dc.contributor.authorAngka, Leonard
dc.date.accessioned2014-08-20T14:44:59Z
dc.date.available2014-08-20T14:44:59Z
dc.date.issued2014-08-20
dc.date.submitted2014
dc.description.abstractTo identify novel anti-cancer agents, we created and screened a unique nutraceutical library for activity against acute myeloid leukemia (AML) cells. From this screen, we determined that glucopsychosine was selectively toxic toward AML cell lines and primary AML patient samples with no effect toward normal hematopoietic cells. It delayed tumor growth and reduced tumor weights in mouse xenograft models without imparting toxicity. Glucopsychosine increased cytosolic calcium and induced apoptosis through calpain enzymes. Extracellular calcium was functionally important for glucopsychosine-induced AML cell death and surface calcium channel expression is altered in AML cells highlighting a unique mechanism of glucopsychosine’s selectivity.en
dc.identifier.urihttp://hdl.handle.net/10012/8660
dc.language.isoenen
dc.pendingfalse
dc.publisherUniversity of Waterlooen
dc.subjectAcute myeloid leukemiaen
dc.subjectNutraceuticalsen
dc.subjectCalciumen
dc.subjectCalpainen
dc.subjectGlucopsychosineen
dc.subject.programPharmacyen
dc.titleGlucopsychosine increases cytosolic calcium to induce calpain-mediated apoptosis of acute myeloid leukemia cells.en
dc.typeMaster Thesisen
uws-etd.degreeMaster of Scienceen
uws-etd.degree.departmentSchool of Pharmacyen
uws.peerReviewStatusUnrevieweden
uws.scholarLevelGraduateen
uws.typeOfResourceTexten

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