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Aptamer-Based Detection of Caffeine and Theophylline Through Utilization of Gold Nanoparticles and Graphene Oxide

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dc.contributor.authorLabas, Sarah
dc.date.accessioned2023-04-26T17:26:57Z
dc.date.available2023-04-26T17:26:57Z
dc.date.issued2023-04-26
dc.date.submitted2023-04-21
dc.description.abstractThe caffeine and theophylline aptamers were used in tandem with gold nanoparticles and graphene oxide to study potential methods for small molecule detection. The AuNP approach is a label-free approach, and the graphene oxide-based sensor is a fluorescence based approach. Each sensor is based off previous literature reporting sensors for DNA targets; more recent literature uses both methods for small molecule detection, but fails to consider target-nanomaterial interactions. The works presented in this thesis serve to determine whether such an interaction exists, and how it may affect the accuracy of the sensors.en
dc.identifier.urihttp://hdl.handle.net/10012/19333
dc.language.isoenen
dc.pendingfalse
dc.publisherUniversity of Waterlooen
dc.subjectaptamersen
dc.subjectbiosensorsen
dc.subjectcaffeineen
dc.subjectgold nanoparticlesen
dc.subjectgraphene oxideen
dc.subjecttheophyllineen
dc.titleAptamer-Based Detection of Caffeine and Theophylline Through Utilization of Gold Nanoparticles and Graphene Oxideen
dc.typeMaster Thesisen
uws-etd.degreeMaster of Scienceen
uws-etd.degree.departmentChemistryen
uws-etd.degree.disciplineChemistryen
uws-etd.degree.grantorUniversity of Waterlooen
uws-etd.embargo.terms0en
uws.contributor.advisorLiu, Juewen
uws.contributor.affiliation1Faculty of Scienceen
uws.peerReviewStatusUnrevieweden
uws.published.cityWaterlooen
uws.published.countryCanadaen
uws.published.provinceOntarioen
uws.scholarLevelGraduateen
uws.typeOfResourceTexten

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