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Identifying the mechanism of Aβ42 inhibition of PDGF-BB signalling

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dc.contributor.authorSaffi, Golam Tanjib
dc.date.accessioned2014-01-23T16:07:44Z
dc.date.available2014-01-23T16:07:44Z
dc.date.issued2014-01-23
dc.date.submitted2013
dc.description.abstractAlzheimer’s disease is a late-onset neurological disorder characterized by extracellular aggregates of Aβ plaques and neurofibrillary tangles of hyperphosphoryated tau protein resulting in neuronal dysfunction, cognitive decline and death. Some of the molecular mechanisms which cause neuronal dysfunction in Alzheimer’s disease are oxidative stress, excitotoxicity and hypoxia. PDGF-BB is a neurotrophic factor which is neuroprotective against these molecular events. However, PDGF-BB failed to be neuroprotective against Aβ42 toxicity in SH-SY5Y neuroblastoma cells. Rather, Aβ42 actually inhibited PDGF-BB signalling and reduced the phosphorylation level at multiple phosphotyrosine sites on the PDGFβ receptor. Aβ42 inhibition of PDGF-BB signalling also inhibited a downstream effector, Akt, a neuroprotective protein. Thus, Aβ42 inhibition of PDGF-BB signalling could worsen oxidative stress, excitotoxicity and hypoxia observed in Alzheimer’s disease. Indeed, Aβ42 treatment prevented PDGF-BB neuroprotection against excitotoxicity. Aβ42 mediated inhibition of PDGF-BB signalling was not due to Aβ42 interaction with PDGFβ receptor. However, it remains inconclusive whether Aβ42 binds to PDGF-BB to prevent PDGF-BB binding to PDGFβ receptor.en
dc.identifier.urihttp://hdl.handle.net/10012/8177
dc.language.isoenen
dc.pendingfalse
dc.publisherUniversity of Waterlooen
dc.subject.programPharmacyen
dc.titleIdentifying the mechanism of Aβ42 inhibition of PDGF-BB signallingen
dc.typeMaster Thesisen
uws-etd.degreeMaster of Scienceen
uws-etd.degree.departmentSchool of Pharmacyen
uws.peerReviewStatusUnrevieweden
uws.scholarLevelGraduateen
uws.typeOfResourceTexten

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