Evaluation and Comparison of Two Novel Non-Platinum-Based Antitumor Agents on Pancreatic Cancer and Triple-Negative Breast Cancer
| dc.contributor.author | Xu, Xiangxuan | |
| dc.date.accessioned | 2022-10-03T12:35:20Z | |
| dc.date.available | 2023-10-04T04:50:03Z | |
| dc.date.issued | 2022-10-03 | |
| dc.date.submitted | 2022-09-20 | |
| dc.description.abstract | Cancer is one of the leading causes threatening human life. People suffering from pancreatic cancer and triple-negative breast cancer (TNBC) have particularly low survival rate among all cancer types. The novel non-platinum based antitumor agents, femtomedicine (FMD) compounds, were discovered as a new class of chemotherapeutic targeting agents to treat multiple cancers. Herein, two of the most effective FMD compounds (FMD-2Br-DAB & FMD-2I-DAB) were evaluated, based on their cytotoxicity against TNBC and pancreatic cancer cells through MTT assay, clonogenic assay, and caspase-3/7 green detection. According to the results obtained from these well-established cell-biology techniques, FMD compounds exhibit good antitumor effects in the cancer cell lines (PANC-1, BXPC-3, and MDA-MB-231), while having minimal impact on the normal cell line (GM05757), indicating FMD compounds can selectively kill TNBC and pancreatic cancer cells without being detrimental to normal cells. Furthermore, FMD-2I-DAB (compound C) shows a better efficiency than FMD-2Br-DAB (compound B), inferring that compound C could be more potent in tumor elimination. This study shows that the FMD compounds, especially for compound C, are potentially new drug candidates for effective treatment of the ‘hard-to-treat’ pancreatic cancer and TNBC. | en |
| dc.identifier.uri | http://hdl.handle.net/10012/18864 | |
| dc.language.iso | en | en |
| dc.pending | false | |
| dc.publisher | University of Waterloo | en |
| dc.title | Evaluation and Comparison of Two Novel Non-Platinum-Based Antitumor Agents on Pancreatic Cancer and Triple-Negative Breast Cancer | en |
| dc.type | Master Thesis | en |
| uws-etd.degree | Master of Science | en |
| uws-etd.degree.department | Physics and Astronomy | en |
| uws-etd.degree.discipline | Physics | en |
| uws-etd.degree.grantor | University of Waterloo | en |
| uws-etd.embargo.terms | 1 year | en |
| uws.contributor.advisor | Lu, Qing-Bin | |
| uws.contributor.affiliation1 | Faculty of Science | en |
| uws.peerReviewStatus | Unreviewed | en |
| uws.published.city | Waterloo | en |
| uws.published.country | Canada | en |
| uws.published.province | Ontario | en |
| uws.scholarLevel | Graduate | en |
| uws.typeOfResource | Text | en |