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pH-Responsive Poly(Ethylene Glycol)- block -Polylactide Micelles for Tumor-Targeted Drug Delivery

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dc.contributor.authorXiao, Lin
dc.contributor.authorHuang, Lixia
dc.contributor.authorMoingeon, Firmin
dc.contributor.authorGauthier, Mario
dc.contributor.authorYang, Guang
dc.date.accessioned2017-08-29T16:56:35Z
dc.date.available2017-08-29T16:56:35Z
dc.date.issued2017-08-16
dc.descriptionThis document is the Accepted Manuscript version of a Published Work that appeared in final form in Biomacromolecules, copyright © American Chemical Society after peer review and technical editing by publisher. To access the final edited and published work see: http://dx.doi.org/10.1021/acs.biomac.7b00509en
dc.description.abstractA biodegradable micellar drug delivery system with a pH-responsive sheddable PEG shell was developed using an acetal-linked poly(ethylene glycol)-block-polylactide (PEG-a-PLA) copolymer and applied to the tumoral release of paclitaxel (PTX). The micelles with a diameter of ∼100 nm were stable in PBS at pH 7.4, started shedding the shell and aggregating slowly at pH 6.5, and decomposed faster at pH 5.5. PTX-loaded micelles (M-PTX) with a drug loading of 6.9 wt % exhibited pH-triggered PTX release in simulated tumoral acidic environments corresponding to the extracellular and intracellular spaces. In vitro experiments showed that the micelles were noncytotoxic to different cell lines, while M-PTX inhibited the proliferation and promoted the apoptosis of Hela cells. An in vivo study with Hela tumor-bearing mice indicated that M-PTX efficiently inhibited tumor growth. Because of these properties, the PEG-a-PLA micellar system appears to have bright prospects as a tumor-targeting drug carrier.en
dc.description.sponsorshipChina Postdoctoral Science Foundation || General Program, No. 18 2015M580640 National Natural Science Foundation of China || General Program, No.19 21574050en
dc.identifier.urihttps://doi.org/10.1021/acs.biomac.7b00509
dc.identifier.urihttp://hdl.handle.net/10012/12267
dc.language.isoenen
dc.publisherAmerican Chemical Societyen
dc.titlepH-Responsive Poly(Ethylene Glycol)- block -Polylactide Micelles for Tumor-Targeted Drug Deliveryen
dc.typeArticleen
dcterms.bibliographicCitationXiao, L., Huang, L., Moingeon, F., Gauthier, M., & Yang. (2017). pH-Responsive Poly(Ethylene Glycol)- block -Polylactide Micelles for Tumor-Targeted Drug Delivery. Biomacromolecules. https://doi.org/10.1021/acs.biomac.7b00509en
uws.contributor.affiliation1Faculty of Scienceen
uws.contributor.affiliation2Chemistryen
uws.peerReviewStatusRevieweden
uws.scholarLevelFacultyen
uws.typeOfResourceTexten

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