Browsing Waterloo Research by Subject "RNA"
Now showing items 1-4 of 4
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A Cleavable Molecular Beacon for Hg2+ Detection based on Phosphorothioate RNA Modifications
(American Chemical Society, 2015-06-10)Mercury is a highly toxic heavy metal, and detection of Hg2+ by biosensors has attracted extensive research interest in the past decade. In particular, a number of DNA-based sensing strategies have been developed. Well-known ... -
A DNAzyme requiring two different metal ions at two distinct sites
(Oxford University Press, 2015-12-10)Most previously reported RNA-cleaving DNAzymes require only a single divalent metal ion for catalysis. We recently reported a general trivalent lanthanide-dependent DNAzyme named Ce13d. This work shows that Ce13d requires ... -
Dysregulated Phosphate Metabolism, Periodontal Disease, and Cancer: Possible Global Health Implications
(MDPI, 2019-02-11)An association between periodontal disease and cancer has been established in recent studies, but no common etiology has been identified in the hopes of reducing the global burden of these non-communicable diseases. This ... -
Ligand Specificity and Affinity in the Sulforhodamine B Binding RNA Aptamer
(Elsevier Inc., 2020-07-18)Binding affinity and selectivity are critical properties of aptamers that must be optimized for any application. The sulforhodamine B binding RNA aptamer (SRB‐2) is a somewhat promiscuous aptamer that can bind ligands ...