Browsing Waterloo Research by Subject "Membrane permeabilization"
Now showing items 1-2 of 2
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Daptomycin forms cation- and size-selective pores in model membranes
(Elsevier, 2014-10)Daptomycin is a lipopeptide antibiotic that is used clinically to treat severe infections caused by Gram-positive bacteria. Its bactericidal action involves the calcium-dependent binding to membranes containing ... -
Mechanistic studies on the effect of membrane lipid acyl chain composition on daptomycin pore formation
(Elsevier, 2018-11-01)Daptomycin is a lipopeptide antibiotic that binds and permeabilizes the cell membranes of Gram-positive bacteria. Membrane permeabilization requires both calcium and phosphatidylglycerol (PG) in the target membrane, and ...