Browsing Waterloo Research by Author "Harris, J. Robin"
Now showing items 1-2 of 2
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Oligomerization and hemolytic properties of the C-terminal domain of pyolysin, a cholesterol-dependent cytolysin
Pokrajac, Lisa A.; Harris, J. Robin; Sarraf, Naghmeh S.; Palmer, Michael (NRC Research Press, 2013-04)Pyolysin (PLO) belongs to the homologous family of the cholesterol-dependent cytolysins (CDCs), which bind to cell membranes containing cholesterol to form oligomeric pores of large size. The CDC monomer structure consists ... -
Partial oligomerization of pyolysin induced by a disulfide-tethered mutant
Pokrajac, Lisa A.; Baik, Clara; Harris, J. Robin; Sarraf, Naghmeh S.; Palmer, Michael (NRC Research Press, 2012-12)The bacterial toxin pyolysin (PLO) belongs to the family of cholesterol-dependent cytolysins (CDCs), which form large, ring-shaped oligomeric pores in cholesterol-containing membranes. Monomeric CDC molecules have a structure ...