Browsing Waterloo Research by Author "Chen, Qingyun"

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DNAzyme Hybridization, Cleavage, Degradation and Sensing in Undiluted Human Blood Serum

Zhou, Wenhu; Chen, Qingyun; Huang, Po-Jung Jimmy; Ding, Jinsong; Liu, Juewen (American Chemical Society, 2015-04-07)

RNA-cleaving DNAzymes provide a unique platform for developing biosensors. However, a majority of the work has been performed in clean buffer solutions, while the activity of some important DNAzymes in biological sample ...
A New Na+-Dependent RNA-Cleaving DNAzyme with over 1000-fold Rate Acceleration by Ethanol

Zhou, Wenhu; Saran, Runjhun; Chen, Qingyun; Ding, Jinsong; Liu, Juewen (Wiley, 2016-01-15)

Enzymes working in organic solvents are important for analytical chemistry, catalysis, and mechanistic studies. Although a few protein enzymes are highly active in organic solvents, little is known regarding nucleic ...
Searching for a DNAzyme version of the leadzyme

Saran, Runjhun; Chen, Qingyun; Liu, Juewen (Springer, 2015-10-12)

The leadzyme refers to a small ribozyme that cleaves a RNA substrate in the presence of Pb2+. In an optimized form, the enzyme strand contains only two unpaired nucleotides. Most RNA-cleaving DNAzymes are much longer. Two ...