Browsing Optometry and Vision Science by Subject "in vitro"
Now showing items 1-5 of 5
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Antifungal ocular drug delivery via contact lenses using a novel in vitro eye model
(University of Waterloo, 2016-04-21)Purpose: The purpose of this thesis was to evaluate the potential of contact lenses (CLs) as an antifungal drug delivery device, and to develop an in vitro eye model to test thereof. Methods: The first three chapters ... -
The combined effects of benzalkonium chloride and ultraviolet radiation on the bovine lens in vitro
(University of Waterloo, 2018-04-23)Purpose: To determine the combined effects of benzalkonium chloride (BAK) and ultraviolet radiation (UV) using the primary culture of intact bovine lenses. Methods: Abattoir-provided lenses were dissected from the eyes ... -
Development of an in vitro eye model to better represent in vivo physiological conditions
(University of Waterloo, 2021-06-23)Purpose The purpose of this thesis was to optimize a novel in vitro blink model, the OcuBlink, to best mimic the physiological characteristics of the human eye. By improving this in vitro model, the results from in vitro ... -
Development of Sensitive In Vitro Assays to Assess the Ocular Toxicity Potential of Chemicals and Ophthalmic Products
(University of Waterloo, 2009-04-27)The utilization of in vitro tests with a tiered testing strategy for detection of mild ocular irritants can reduce the use of animals for testing, provide mechanistic data on toxic effects, and reduce the uncertainty ... -
Toxicity of Ophthalmic Solutions, Benzalkonium Chloride and UV Radiation on Human Corneal Epithelial Cells in vitro
(University of Waterloo, 2015-06-12)The purpose of this work was to develop a sensitive in vitro method for ocular toxicity testing; and to use this method to assess the individual and combined effects of ophthalmic solutions, benzalkonium chloride (BAK), ...