Browsing Optometry and Vision Science by Subject "Drug delivery"
Now showing items 1-5 of 5
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Acetic and Acrylic Acid Molecular Imprinted Model Silicone Hydrogel Materials for Ciprofloxacin-HCl Delivery
(Multidisciplinary Digital Publishing Institute, 2012-01-02)Contact lenses, as an alternative drug delivery vehicle for the eye compared to eye drops, are desirable due to potential advantages in dosing regimen, bioavailability and patient tolerance/compliance. The challenge has ... -
Development of an In Vitro Ocular Platform to Test Contact Lenses
(Journal of Visualized Experiments, 2016-06-04)Currently, in vitro evaluations of contact lenses (CLs) for drug delivery are typically performed in large volume vials,1-6 which fail to mimic physiological tear volumes.7 The traditional model also lacks the natural tear ... -
Extended Latanoprost Release from Commercial Contact Lenses: In Vitro Studies Using Corneal Models
(Public Library of Science, 2014-10-09)In this study, we compared, for the first time, the release of a 432 kDa prostaglandin analogue drug, Latanoprost, from commercially available contact lenses using in vitro models with corneal epithelial cells. Conventional ... -
In Vitro and In Vivo Evaluation of Novel Ciprofloxacin-Releasing Silicone Hydrogel Contact Lenses
(Association for Research in Vision and Ophthalmology, 2014-08-08)Purpose.: The purpose of this study was to evaluate ciprofloxacin-releasing silicone hydrogel contact lens materials in vitro and in vivo for the treatment of microbial keratitis. Methods.: Model silicone hydrogel contact ... -
Release of Ciprofloxacin and Moxifloxacin From Daily Disposable Contact Lenses From an In Vitro Eye Model
(Association for Research in Vision and Ophthalmology, 2015-10-04)Purpose.: To analyze the release of two fluoroquinolones, ciprofloxacin and moxifloxacin, from conventional hydrogel (CH) and silicone hydrogel (SH) daily disposable contact lenses (CLs), comparing release from a fixed-volume ...