Browsing Science (Faculty of) by Subject "SOD1"
Now showing items 1-3 of 3
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Immature SOD1: protein folding, misfolding and aggregation
(University of Waterloo, 2023-01-25)Protein misfolding and aggregation are hallmarks of many diseases, including amyotrophic lateral sclerosis (ALS). In familial ALS, aberrant self-association of mutant Cu,Zn-superoxide dismutase (SOD1) is implicated as a ... -
Investigation of Immature Cu,Zn Superoxide Dismutase 1 Using Variable Temperature NMR
(University of Waterloo, 2020-09-03)Amyotrophic lateral sclerosis (ALS) is an adult onset neurodegenerative disease that results in the death of motor neurons in the spinal cord, cortex, and brain stem. The vast majority of ALS cases arise sporadically, but ... -
Spectrophotometric method for simultaneous measurement of zinc and copper in metalloproteins using 4-(2-pyridylazo)resorcinol
(Elsevier, 2019-08-15)Bound metals are observed in a great many natural proteins, where they perform diverse roles in determining protein folding, stability and function. Due to the broad impact of bound metals on biophysical and biochemical ...