Browsing Science (Faculty of) by Subject "DNA Replication"
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Characterization of Dbf4 structure and function in Saccharomyces cerevisiae DNA replication and checkpoint responses.
(University of Waterloo, 2014-02-21)The Dbf4/Cdc7 kinase complex is required for the initiation of DNA replication and promotes this by acting upon members of the Mcm2-7 helicase. In addition to its role in replication, Dbf4/Cdc7 is a target of the S-phase ... -
Functional Characterization of the Origin Recognition Complex (ORC) in S. cerevisiae
(University of Waterloo, 2008-01-23)The origin recognition complex (Orc1-6) plays a fundamental role in the initiation of DNA replication by binding replication origins throughout the budding yeast cell cycle. ORC acts as a scaffold for the assembly of the ...