Browsing Health (Faculty of) by Author "Bradley, Ryan M."
Now showing items 1-3 of 3
-
Agpat4/Lpaat delta deficiency highlights the molecular heterogeneity of epididymal and perirenal white adipose depots
Mardian, Emily B.; Bradley, Ryan M.; Henao, Juan J. Aristizabal; Marvyn, Phillip M.; Moes, Katherine A.; Bombardier, Eric; Tupling, A. Russell; Stark, Ken; Duncan, Robin E. (American Society for Biochemistry and Molecular Biology, 2017-10-01)Acylglycerophosphate acyltransferase 4 (AGPAT4)/lysophosphatidic acid acyltransferase delta catalyzes the formation of phosphatidic acid (PA), a precursor of triacylglycerol (TAG). We investigated the effect of Agpat4 gene ... -
Functional characterization of murine 1-acylglycerol-3-phosphate O-acyltransferase 4 (AGPAT4)
Bradley, Ryan M. (University of Waterloo, 2015-09-30)The human genome project has allowed for the rapid identification of a large number of protein families based on similarities in their genetic sequences. The acyl-glycerol phosphate acyltransferase (AGPAT) family of enzymes ... -
Identification and characterization of a novel microsomal enzyme involved in cardiolipin synthesis and remodeling
Bradley, Ryan M. (University of Waterloo, 2018-05-17)Cardiolipin (CL) is a specialized dimeric phospholipid predominantly found in the inner mitochondrial membrane in eukaryotes. Following de novo synthesis, the acyl chains of CL are remodeled in a manner that is tissue- and ...