Browsing Theses by Subject "insulin signalling"
Now showing items 1-2 of 2
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Effects of high-fat feeding on skeletal muscle insulin signalling in sarcolipin knockout mice
(University of Waterloo, 2010-08-26)Type II diabetes mellitus (T2DM) has been associated with the onset of diet-induced obesity, which is currently on the rise worldwide. T2DM is typically characterized by insulin resistance in peripheral tissues such as ... -
Two-weeks of single-leg immobilization alters IMCL storage, mitochondrial content, and insulin signalling in healthy, young women
(University of Waterloo, 2019-05-23)During limb immobilization and bed rest, there is a significant loss of muscle mass and strength, and an onset of insulin resistance (IR). Subcellular localization of intramyocellular lipids (IMCL) is suggested to regulate ...