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dc.contributor.authorSoltani, Mohammad 12:46:32 (GMT)
dc.description.abstractContinuous health monitoring systems are an essential part of current and future life. Monitoring biological signals helps us detect health issues in the early stages. Besides the early-stage disease diagnosis, some patients also need a continuous system to monitor their physical condition continuously. In this research, we focused on two types of monitoring systems. The first type of sensor has been used to detect and prevent complications in surgical operations and then determine the need for post-operational treatments. Abdominal surgery, generally done for removing some part of the digestive system, is one of the most common of surgical operations. One common complication after this type of surgery is the anastomotic leak. This complication is among the most dreadened problems that happen to the patients, typically one or two weeks after the surgery. This dreadened issue can be readily prevented using a continuous monitoring system that detects abnormal pH variations in the abdominal fluid. This research shows a possible approach to monitoring point-of-care (POC) and preventive action toward this complication using an electrochemical on-chip pH sensing system. The second part of this research focused on a continuous glucose monitoring system to monitor interstitial fluid glucose concentration. Continuously monitoring blood glucose levels attracts considerable attention due to high complications in diabetic patients. The vast increase in people with diabetes due to the current human lifestyle makes it essential to fabricate a lower-cost monitoring system that can detect glucose and other biological parameters. To efficiently monitor glucose levels and detect other parameters that affect glucose monitoring, we proposed a platform that can simultaneously be used with several bio-signals, such as glucose concentration and pH level. An electrochemical multiplexed sensing platform has been developed to detect these biological signals from interstitial fluid (ISF). To improve the capabilities of this device, the fabrication has been done on a flexible substrate. Using self-assembly nanostructure processing methods and materials synthesis, some novel forms of self-assembled nanostructure have been investigated that can improve the sensing capabilities of the fabricated flexible electrodes. New materials such as semiconducting oxides and their effect on sensing capabilities have been discussed, and possible future directions have been proposed. Also, to extract ISF efficiently, polymeric microneedle arrays have been implemented with the device to extract and bring the ISF to the surface of the electrodes for detection.en
dc.publisherUniversity of Waterlooen
dc.titleMiniaturization of Multiplexed sensor for continuous health monitoring systemsen
dc.typeDoctoral Thesisen
dc.pendingfalse and Computer Engineeringen and Computer Engineeringen of Waterlooen
uws-etd.degreeDoctor of Philosophyen
uws-etd.embargo.terms2 yearsen
uws.contributor.advisorCui, Bo
uws.contributor.affiliation1Faculty of Engineeringen

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