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dc.contributor.authorFletcher, Randy
dc.date.accessioned2022-01-25 14:53:32 (GMT)
dc.date.issued2022-01-25
dc.date.submitted2022-01-19
dc.identifier.urihttp://hdl.handle.net/10012/17959
dc.description.abstractThe intramolecular electrophilic aromatic amination of secondary amides was developed. Secondary N-methoxy and N-p-methoxyphenyl amides were cyclized to oxindoles by triflic anhydride mediated electrophilic activation and subsequent oxidation with a pyridine N-oxide derivative. The electrophilic nitrogen species for the N-methoxy amide was isolated and characterized. Aryl tethered 2-amidopyridine- and 2-amidopyrimidine N-oxides were additionally discovered to be synthetically valuable sources of electrophilic nitrogen under mild conditions following a simple activation protocol of triflic anhydride and tertiary amine base.en
dc.language.isoenen
dc.publisherUniversity of Waterlooen
dc.subjectorganic synthesisen
dc.subjectmethodologyen
dc.subjectelectrophilic aminationen
dc.subjectsecondary amidesen
dc.subjectumpolungen
dc.titleMethodology Development for the Electrophilic Aromatic Amination of Secondary Amidesen
dc.typeMaster Thesisen
dc.pendingfalse
uws-etd.degree.departmentChemistryen
uws-etd.degree.disciplineChemistryen
uws-etd.degree.grantorUniversity of Waterlooen
uws-etd.degreeMaster of Scienceen
uws-etd.embargo.terms2 yearsen
uws.contributor.advisorFillion, Eric
uws.contributor.affiliation1Faculty of Scienceen
uws.published.cityWaterlooen
uws.published.countryCanadaen
uws.published.provinceOntarioen
uws-etd.embargo2024-01-25T14:53:32Z
uws.typeOfResourceTexten
uws.peerReviewStatusUnrevieweden
uws.scholarLevelGraduateen


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