Show simple item record

dc.contributor.authorLivingstone, James David
dc.date.accessioned2020-12-09 16:34:32 (GMT)
dc.date.issued2020-12-09
dc.date.submitted2020-11-18
dc.identifier.urihttp://hdl.handle.net/10012/16527
dc.description.abstractThe use of lithium in treatment of mental illnesses like bipolar disorder, major depressive disorder, and schizophrenia dates to the mid 20th century. Some research also indicates that the symptoms of Alzheimer’s Disease can be lessened by lithium treatment. But despite widespread use, the complete mechanisms through which lithium works are largely unknown. The “isotopically impure” lithium used to treat these disorders is comprised of approximately 7.59% ⁶Li and 92.41% ⁷Li, about the normal distribution of the lithium isotopes in nature. Pharmacologically, no distinction has been made between the two isotopes. However, preliminary animal model research suggests that these isotopes may have differential effects on the maternal behaviours of rats, while other cellular research has found a difference in the sustained concentration of each isotope in both neural cells and erythrocytes. The research presented here investigates the possibility that the isotopes ⁶Li and ⁷Li may have different effects on neuronal physiology and molecular processes. No significant difference was found on the rate of glycogen synthase kinase-3-β (GSK-3-β) activity, GSK-3-β phosphorylation rates in HT22 cells, or HT22 cell viability when treated with ⁶Li and ⁷Li. However, a possible difference has been found in the sustained lithium isotope concentrations across the HT22 plasma membrane. More research is needed to confirm and elucidate this global set of data, but the results presented here indicate a reasonable possibility that lithium isotopes are differentially fractionated across the HT22 plasma membrane.en
dc.language.isoenen
dc.publisherUniversity of Waterlooen
dc.subjectlithiumen
dc.subjectisotopeen
dc.subject⁷Lien
dc.subject⁶Lien
dc.subjectGSK-3-βen
dc.subjectHT22en
dc.subjectHT-22en
dc.subjectquantum biologyen
dc.subjectneuronen
dc.subjectJames Livingstoneen
dc.titleThe Compared Effects of Lithium Isotopes ⁶Li and ⁷Li on GSK-3-β Activity and the Biochemistry of HT22 Neuronal Cellsen
dc.typeMaster Thesisen
dc.pendingfalse
uws-etd.degree.departmentBiologyen
uws-etd.degree.disciplineBiologyen
uws-etd.degree.grantorUniversity of Waterlooen
uws-etd.degreeMaster of Scienceen
uws-etd.embargo.terms2 yearsen
uws.contributor.advisorLeonenko, Zoya
uws.contributor.affiliation1Faculty of Scienceen
uws.published.cityWaterlooen
uws.published.countryCanadaen
uws.published.provinceOntarioen
uws-etd.embargo2022-12-09T16:34:32Z
uws.typeOfResourceTexten
uws.peerReviewStatusUnrevieweden
uws.scholarLevelGraduateen


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record


UWSpace

University of Waterloo Library
200 University Avenue West
Waterloo, Ontario, Canada N2L 3G1
519 888 4883

All items in UWSpace are protected by copyright, with all rights reserved.

DSpace software

Service outages