A new perspective on loss to follow-up in failure time and life history studies
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Date
2019-07-24
Authors
Lawless, Jerald F.
Cook, Richard J.
Journal Title
Journal ISSN
Volume Title
Publisher
Wiley
Abstract
A framework is proposed for the joint modeling of life history and loss to follow-up (LTF) processes
in cohort studies. This framework provides a basis for discussing independence conditions
for LTF and censoring and examining the implications of dependent LTF.We consider failure time
and more general life history processes. The joint models are based on multistate processes with
expanded state spaces encompassing both the life history and LTF processes. Tracing studies are
discussed as a means of investigating the presence of dependent censoring and providing valid
estimates of transition intensities and state occupancy probabilities. Simulation studies and an
illustration based on a cohort of individuals with systemic lupus erythematosus demonstrate the
usefulness and properties of the proposed methods.
Description
This is the peer reviewed version of the following article: Jerald F. Lawless and Richard
J. Cook, A new perspective on loss to follow-up in failure time and life history studies.
Statistics in Medicine (2019), 38(23): 4583–4610 which has been published in final form
at https://doi.org/10.1002/sim.8318.
Keywords
auxiliary data, independent censoring, life history process, loss to follow-up, multistate model, tracing studies