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dc.contributor.authorLinley, Stuart
dc.contributor.authorHolmes, Andrew
dc.contributor.authorLeshuk, Timothy
dc.contributor.authorNafo, Wanis
dc.contributor.authorThomson, Neil R.
dc.contributor.authorAl-Mayah, Adil
dc.contributor.authorMcVey, Kevin
dc.contributor.authorSra, Kanwartej
dc.contributor.authorGu, Frank X. 18:59:45 (GMT) 18:59:45 (GMT)
dc.descriptionThe final publication is available at Elsevier via © 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
dc.description.abstractTargeted nanoparticle binding has become a core feature of experimental pharmaceutical product design which enables more efficient payload delivery and enhances medical imaging by accumulating nanoparticles in specific tissues. Environmental remediation and geophysical monitoring encounter similar challenges which may be addressed in part by the adoption of targeted nanoparticle binding strategies. This study illustrates that engineered nanoparticles can bind to crude oil-impacted silica sand, a selective adsorption driven by active targeting based on an amphiphilic polymer coating. This coating strategy resulted in 2 mg/kg attachment to clean silica sand compared to 8 mg/kg attachment to oil-impacted silica sand. It was also shown that modifying the surface coating influenced the binding behaviour of the engineered nanoparticles – more hydrophobic polymers resulted in increased binding. Successful targeting of Pluronic-coated iron oxide nanoparticles to a crude oil and silica sand mixture was demonstrated through a combined quantitative Orbital Emission Spectroscopy mass analysis supported by Vibrating Scanning Magnetometer magnetometry, and a qualitative X-ray micro-computed tomography (CT) visualization approach. These non-destructive characterization techniques facilitated efficient analysis of nanoparticles in porous medium samples with minimal sample preparation, and in the case of X-Ray CT, illustrated how targeted nanoparticle binding may be used to produce 3-D images of contaminated porous media. This work demonstrated successful implementation of nanoparticle targeted binding toward viscous LNAPL such as crude oil in the presence of a porous medium, a step which opens the door to successful application of targeted delivery technology in environmental remediation and monitoring.en
dc.description.sponsorshipNatural Sciences and Engineering Research Council of Canadaen
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.titleTargeted nanoparticle binding & detection in petroleum hydrocarbon impacted porous mediaen
dcterms.bibliographicCitationLinley, S., Holmes, A., Leshuk, T., Nafo, W., Thomson, N. R., Al-Mayah, A., … Gu, F. X. (2019). Targeted nanoparticle binding & detection in petroleum hydrocarbon impacted porous media. Chemosphere, 215, 353–361. doi:10.1016/j.chemosphere.2018.10.046en
uws.contributor.affiliation1Faculty of Engineeringen
uws.contributor.affiliation1Faculty of Scienceen
uws.contributor.affiliation2Chemical Engineeringen
uws.contributor.affiliation2Waterloo Institute for Nanotechnology (WIN)en

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