LIGAND TRANSFER REACTIONS OF HYPERVALENT IODINE REAGENTS WITH PHOSPHORUS COMPOUNDS

Abstract

Many hypervalent iodine compounds are used as versatile reagents in synthetic organic chemistry. Hypervalent iodine reagents are capable of oxidizing trivalent phosphorus compounds into pentavalent, by transferring their heteroatom ligands onto phosphorus. These pentavalent phosphorus compounds can have a different reactivity profile than either the hypervalent iodine(III) reagents or the parent phosphorus(III) compounds. As such, in addition to their applications in organic reactions, they are utilized in fields such as medicinal chemistry, biochemistry, and chemical biology. The goal of this project is to synthesize pentavalent phosphorus species from trivalent phosphorus compounds using relatively cheap, environmentally benign, hypervalent iodine reagents.