dc.contributor.author | Jeon, Chanil | |
dc.contributor.author | Hyeon, Changbong | |
dc.contributor.author | Jung, Youngkyun | |
dc.contributor.author | Ha, Bae-Yeun | |
dc.date.accessioned | 2017-11-07 16:22:19 (GMT) | |
dc.date.available | 2017-11-07 16:22:19 (GMT) | |
dc.date.issued | 2016-10-21 | |
dc.identifier.uri | http://dx.doi.org/10.1039/c6sm01924b | |
dc.identifier.uri | http://hdl.handle.net/10012/12616 | |
dc.description.abstract | In a crowded cellular interior, dissolved biomolecules or crowders exert excluded volume effects on other biomolecules, which in turn control various processes including protein aggregation and chromosome organization. As a result of these effects, a long chain molecule can be phase-separated into a condensed state, redistributing the surrounding crowders. Using computer simulations and a theoretical approach, we study the interrelationship between molecular crowding and chain organization. In a parameter space of biological relevance, the distributions of monomers and crowders follow a simple relationship: the sum of their volume fractions rescaled by their size remains constant. Beyond a physical picture of molecular crowding it offers, this finding explains a few key features of what has been known about chromosome organization in an E. coli cell. | en |
dc.description.sponsorship | NSERC (Canada) | en |
dc.description.sponsorship | Korea Institute of Science and Technology Information (KISTI) | en |
dc.description.sponsorship | Basic Science Research Program [2015R1D1A1A09057469] | en |
dc.description.sponsorship | KIAS (Korea Institute for Advanced Study) | en |
dc.language.iso | en | en |
dc.publisher | Royal Society of Chemistry | en |
dc.subject | Escherichia-Coli Chromosome | en |
dc.subject | Rna-Polymerase | en |
dc.subject | Physiological Consequences | en |
dc.subject | Bacterial Chromosomes | en |
dc.subject | Dynamics Simulation | en |
dc.subject | Ring Polymer | en |
dc.subject | Confinement | en |
dc.subject | Dna | en |
dc.subject | Transcription | en |
dc.subject | Interact | en |
dc.title | How are molecular crowding and the spatial organization of a biopolymer interrelated | en |
dc.type | Article | en |
dcterms.bibliographicCitation | Jeon, C., Hyeon, C., Jung, Y., & Ha, B.-Y. (2016). How are molecular crowding and the spatial organization of a biopolymer interrelated. Soft Matter, 12(48), 9786–9796. https://doi.org/10.1039/C6SM01924B | en |
uws.contributor.affiliation1 | Faculty of Science | en |
uws.contributor.affiliation2 | Physics and Astronomy | en |
uws.typeOfResource | Text | en |
uws.peerReviewStatus | Reviewed | en |
uws.scholarLevel | Faculty | en |