Use of (Dihaloiodo)arene Reagents in Halogenation Reactions

Abstract

Halogenation of organic molecules is a fundamental transformation in organic chemistry. Introducing halogens into substrates can be a challenge since most methods for introducing fluorine or chlorine into molecules include the use of toxic reagents, harsh reaction conditions or expensive reagents. In recent years, hypervalent iodine compounds have garnered much interest due to their reactivity, their ease of synthesis and their mild reaction conditions, and they have been successfully employed in numerous halogenation reactions. My master’s thesis has been focused on two projects, deoxygenative chlorination using iodobenzene dichloride and denitrogenative hydrofluorination using iodotoluene difluoride.