Show simple item record

dc.contributor.authorFernandez, Haya 20:34:01 (GMT) 20:34:01 (GMT)
dc.description.abstractEpilepsy has been associated with an increased fracture risk by various studies in the literature. This is attributed to the decreased bone mineral density (BMD) linked to the anti–epileptic drugs (AEDs) that are used to control seizures. As increasing age is also associated with decreasing BMD, older adults with epilepsy are at particular risk for fracture. There is no consensus on managing this risk and many epilepsy care guidelines do not address the risk at all. This is understandable considering the lack of adequate research on counteractive measures in this specific population. Moreover, though a prevailing theory explains the observed decreased BMD to be a result of AEDs reducing active vitamin D levels, the efficacy of vitamin D supplementation as a protective measure does not have robust evidence nor is there an agreed upon treatment regimen. The proposed project will aim to fill the gaps in the research and establish groundwork for future research on prevention and treatment by: examining the existing literature on vitamin D supplementation for bone health in adults with epilepsy; investigating the prevalence of osteoprotective behaviours and their impact on fracture occurrence in older Canadian adults with and without epilepsy; and determining the prevalence of vitamin D supplementation in the older adult Canadian epileptic population.en
dc.publisherUniversity of Waterlooen
dc.subjectbone healthen
dc.titleBone health in adults with epilepsyen
dc.typeMaster Thesisen
dc.pendingfalse of Pharmacyen of Waterlooen
uws-etd.degreeMaster of Scienceen
uws.contributor.advisorTejal, Patel
uws.contributor.affiliation1Faculty of Scienceen

Files in this item


This item appears in the following Collection(s)

Show simple item record


University of Waterloo Library
200 University Avenue West
Waterloo, Ontario, Canada N2L 3G1
519 888 4883

All items in UWSpace are protected by copyright, with all rights reserved.

DSpace software

Service outages