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dc.contributor.authorLu, Chang
dc.contributor.authorLiu, Yibo
dc.contributor.authorYing, Yibin
dc.contributor.authorLiu, Juewen 16:11:58 (GMT) 16:11:58 (GMT)
dc.descriptionThis document is the Accepted Manuscript version of a Published Work that appeared in final form in Langmuir, © 2017 American Chemical Society after peer review and technical editing by publisher. To access the final edited and published work see Lu, C., Liu, Y., Ying, Y., & Liu, J. (2017). Comparison of MoS2, WS2, and Graphene Oxide for DNA Adsorption and Sensing. Langmuir, 33(2), 630–637.
dc.description.abstractInterfacing DNA with two-dimensional (2D) materials has been intensely researched for various analytical and biomedical applications. Most of these studies have been performed on graphene oxide (GO) and two metal dichalcogenides, molybdenum disulfide (MoS2) and tungsten disulfide (WS2); all of them can all adsorb single-stranded DNA. However, they use different surface forces for adsorption based on their chemical structures. In this work, fluorescently labeled DNA oligonucleotides were used and their adsorption capacities and kinetics were studied as a function of ionic strength, DNA length, and sequence. Desorption of DNA from these surfaces was also measured. DNA is more easily desorbed from GO by various denaturing agents, whereas surfactants yield more desorption from MoS2 and WS2. Our results are consistent with the fact that DNA can be adsorbed by GO via pi-pi stacking and hydrogen bonding, and MoS, and WS2 mainly use van der Waals force for adsorption. Finally, fluorescent DNA probes were adsorbed by these 2D materials for detecting complementary DNA. For this assay, GO gave the highest sensitivity, whereas they all showed a similar detection limit. This study has enhanced our fundamental understanding of DNA adsorption by two important types of 2D materials and is useful for further rational optimization of their analytical and biomedical applications.en
dc.description.sponsorshipNatural Sciences and Engineering Research Council of Canada (NSERC); Doctoral Fund for Priority Development Project from Ministry of Education of China [20120101130009]en
dc.publisherAmerican Chemical Societyen
dc.subjectFluorescent Biosensoren
dc.subjectSensitive Detectionen
dc.subjectMonolayer Mos2en
dc.subjectLayered Mos2en
dc.titleComparison of MoS2, WS2, and Graphene Oxide for DNA Adsorption and Sensingen
dcterms.bibliographicCitationLu, C., Liu, Y., Ying, Y., & Liu, J. (2017). Comparison of MoS2, WS2, and Graphene Oxide for DNA Adsorption and Sensing. Langmuir, 33(2), 630–637.
uws.contributor.affiliation1Faculty of Scienceen
uws.contributor.affiliation3Waterloo Institute for Nanotechnology (WIN)en

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