Copper-mediated C-S Bond Formation and C(sp2)-H Functionalization via Cascade Cyclization
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Organosulfur compounds have a wide variety of applications in pharmaceutical compounds and synthetic materials. Carbon-sulfur bonds are often found in natural and important bioactive compounds, thus the formation of C-S bonds is of high research interest. A novel method has been discovered to generate C-S bonds in tandem with C-C bond formation. This new reaction starts with aryl diynes and a sulfinate salt under copper-mediated conditions to form a new C-S bond and two new C-C bonds, which involves the functionalization of an aromatic C-H bond and a formal [3+2] cycloaddition. This thesis will discuss the reaction optimization, reaction scope and preliminary mechanistic investigations.
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Tianyu Yang (2016). Copper-mediated C-S Bond Formation and C(sp2)-H Functionalization via Cascade Cyclization. UWSpace. http://hdl.handle.net/10012/10933