Browsing University of Waterloo by Subject "insulin secretion"
Now showing items 1-2 of 2
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Isoform-specific Roles of Prolyl-Hydroxylases in the Regulation of β-cell Insulin Secretion during Diet-Induced Obesity in Males
(University of Waterloo, 2024-06-13)Type 2 diabetes affects approximately 480 million individuals worldwide and is associated with impaired tissue insulin sensitivity and β-cell dysfunction. Although there has been much research into nutrient-regulated insulin ... -
Mechanistic Role of ARNT/HIF-1β in the Regulation of Glucose-Stimulated Insulin Secretion
(University of Waterloo, 2014-04-29)Loss of glucose-stimulated insulin secretion (GSIS) from the pancreatic beta-cells is one of the earliest detectable defects in the pathogenesis of type 2 diabetes. However, despite its relevance, the mechanisms that govern ...