Browsing University of Waterloo by Subject "Meldrum's acid"
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The Catalytic Intramolecular Friedel-Crafts Acylation of Meldrum's Acid Derivatives and The Total Synthesis of Taiwaniaquinol B
(University of Waterloo, 2005)The intramolecular Friedel-Crafts acylation of aromatics with Meldrum?s acid derivatives catalyzed by metal trifluoromethanesulfonates and other Lewis acids is reported. Meldrum?s acids are easily prepared, functionalized, ... -
Enantioselective Conjugate Additions to Meldrum’s Acid Acceptors for the Synthesis of Quaternary Centres and Studies on Persistent Intramolecular C–H•••X (X = O, S, Br, Cl, and F) Hydrogen Bonds Involving Benzyl Meldrum’s Acids
(University of Waterloo, 2009-08-31)The construction of benzylic quaternary stereocentres via the enantioselective copper-catalyzed 1,4-addition of dialkylzinc reagents to Meldrum’s acid acceptors in the presence of a phosphoramidite ligand is reported. ... -
Innovative Methods for the Catalyzed Construction of Carbon-Carbon and Carbon-Hydrogen Bonds
(University of Waterloo, 2012-09-26)The selective transformation of carbon-carbon and carbon-hydrogen bonds represents an attractive approach and rapidly developing frontier in synthesis. Benefits include step and atom economy, as well as the ubiquitous ...