Browsing University of Waterloo by Author "Yu, Tianmeng"
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Cr3+ Binding to DNA Backbone Phosphate and Bases: Slow Ligand Exchange Rates and Metal Hydrolysis
Zhou, Wenhu; Yu, Tianmeng; Vazin, Mahsa; Ding, Jinsong; Liu, Juewen (American Chemical Society, 2017-06-07)The interaction between chromium ions and DNA is of great interest in inorganic chemistry, toxicology, and analytical chemistry. Most previous studies focused on in situ reduction of Cr(VI), producing Cr3+ for DNA binding. ... -
A Highly Active RNA-Cleaving DNAzyme with Accelerated Activity by Ethanol and by Freezing
Yu, Tianmeng (University of Waterloo, 2018-04-27)DNAzymes are functional DNA molecules with catalytic activities. The EtNa is an example of a RNA-cleaving DNAzyme that catalyzes the cleavage reaction of a phosphodiester bond in the presence of metal ions, such as Na+ or ... -
In Vitro Selection of Chromium-Dependent DNAzymes for Sensing Chromium(III) and Chromium(VI)
Zhou, Wenhu; Vazin, Mahsa; Yu, Tianmeng; Ding, Jinsong; Liu, Juewen (Wiley, 2016-07-04)Chromium is a very important analyte for environmental monitoring, and developing biosensors for chromium is a long-standing analytical challenge. In this work, in vitro selection of RNA-cleaving DNAzymes was carried out ...