Browsing University of Waterloo by Author "Silverman, Jared"
Now showing items 1-3 of 3
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Cardiolipin Prevents Membrane Translocation and Permeabilization by Daptomycin
Zhang, TianHua; Muraih, Jawad K.; Tishbi, Nasim; Herskowitz, Jennifer; Victor, Rachel L.; Silverman, Jared; Uwumarenogie, Stephanie; Taylor, Scott D.; Palmer, Michael; Mintzer, Evan (American Society for Biochemistry and Molecular Biology, 2014-04-25)Daptomycin is an acidic lipopeptide antibiotic that, in the presence of calcium, forms oligomeric pores on membranes containing phosphatidylglycerol. It is clinically used against various Gram-positive bacteria such as ... -
Daptomycin forms cation- and size-selective pores in model membranes
Zhang, TianHua; Muraih, Jawad K.; MacCormick, Ben; Silverman, Jared; Palmer, Michael (Elsevier, 2014-10)Daptomycin is a lipopeptide antibiotic that is used clinically to treat severe infections caused by Gram-positive bacteria. Its bactericidal action involves the calcium-dependent binding to membranes containing ... -
Mutual inhibition through hybrid oligomer formation of daptomycin and the semisynthetic lipopeptide antibiotic CB-182,462
Zhang, TianHua; Mintzer, Evan; Tishbi, Nasim; Desert, Celine; Silverman, Jared; Taylor, Scott D.; Palmer, Michael (Elsevier, 2013-02)Daptomycin is a clinically important lipopeptide antibiotic that kills Gram-positive bacteria through membrane depolarization. Its activity requires calcium and the presence of phosphatidylglycerol in the target membrane. ...