Browsing University of Waterloo by Author "Slavcev, Roderick"
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Bacteriophage interactions with mammalian tissue: Therapeutic applications
Huh, Haein; Wong, Shirley; St. Jean, Jesse; Slavcev, Roderick (Elsevier, 2019-05)The human body is a large reservoir for bacterial viruses known as bacteriophages (phages), which participate in dynamic interactions with their bacterial and human hosts that ultimately affect human health. The current ... -
Construction and analysis of a genetically tuneable lytic phage display system
Nicastro, Jessica; Sheldon, Katlyn; El-zarkout, Farah A.; Sokolenko, Stanislav; Aucoin, Marc; Slavcev, Roderick (Springer, 2013-09-01)The Bacteriophage lambda capsid protein gpD has been used extensively for fusion polypeptides that can be expressed from plasmids in Escherichia coli and remain soluble. In this study, a genetically controlled dual expression ... -
Immunogenicity and antitumor activity of the superlytic λF7 phage nanoparticles displaying a HER2/neu-derived peptide AE37 in a tumor model of BALB/c mice
Barati, Nastaran; Razazan, Atefeh; Nicastro, Jessica; Slavcev, Roderick; Arab, Atefeh; Mosaffa, Fatemeh; Nikpoor, Amin Reza; Badiee, Ali; Jaafari, Mahmoud Reza; Behravan, Javad (Elsevier, 2018-06-28)Phage display technique has been increasingly researched for vaccine design and delivery strategies in recent years. In this study, the AE37 (Ii-Key/HER-2/neu 776–790) peptide derived from HER2 (human epidermal growth ...