Browsing Waterloo Research by Author "Pawliszyn, Janusz"
Now showing items 21-40 of 55
-
The effect of hematocrit on solid-phase microextraction
Reyes-Garcés, Nathaly; Alam, Md. Nazmul; Pawliszyn, Janusz (Elsevier, 2018-02-25)Solid-phase microextraction (SPME) is an approach to sample preparation that has demonstrated its appropriateness for isolating/enriching analytes present in complex biofluids with minimum sample pre-treatment. Several ... -
Equilibrium ex vivo calibration of homogenized tissue for in vivo SPME quantitation of doxorubicin in lung tissue
Roszkowska, Anna; Tascon, Marcos; Bojko, Barbara; Goryński, Krzysztof; dos Santos, Pedro Reck; Cypel, Marcelo; Pawliszyn, Janusz (Elsevier, 2018-06-01)The fast and sensitive determination of concentrations of anticancer drugs in specific organs can improve the efficacy of chemotherapy and minimize its adverse effects. In this paper, ex vivo solid-phase microextraction ... -
Exploiting the tunable selectivity features of polymeric ionic liquid-based SPME sorbents in food analysis
Gionfriddo, Emanuela; Souza-Silva, Erica A.; Ho, Tien D.; Anderson, Jared L.; Pawliszyn, Janusz (Elsevier, 2018-10-01)In this work, the performances of polymeric ionic liquid (PIL) based solid-phase microextraction (SPME) coatings were assessed for applications concerning food safety and quality. Two different polymeric ionic liquid ... -
A facile and fully automated on-fiber derivatization protocol for direct analysis of short-chain aliphatic amines using a matrix compatible solid-phase microextraction coating
Gionfriddo, Emanuela; Passarini, Alice; Pawliszyn, Janusz (Elsevier, 2017-07-29)Solid-phase microextraction (SPME) analysis of short-chain aliphatic amines (C-3-C-6) in aqueous solutions was investigated using pentafluorobenzaldehyde (PFBAY) as on-fiber derivatization reagent. A standard gas generating ... -
Fast quantitation of opioid isomers in human plasma by differential mobility spectrometry/mass spectrometry via SPME/open-port probe sampling interface
Liu, Chang; Gómez-Ríos, Germán Augusto; Schneider, Bradley B.; Le Blanc, J. C. Yves; Reyes-Garcés, Nathaly; Arnold, Don W.; Covey, Thomas R.; Pawliszyn, Janusz (Elsevier, 2017-10-23)Mass spectrometry (MS) based quantitative approaches typically require a thorough sample clean-up and a decent chromatographic step in order to achieve needed figures of merit. However, in most cases, such processes are ... -
Fast Quantitation of Target Analytes in Small Volumes of Complex Samples by Matrix-Compatible Solid-Phase Microextraction Devices
Piri-Moghadam, Hamed; Ahmadi, Fardin; Reyes-Garcés, Nathaly; Boyaci, Ezel; Reyes-Garces, Nathaly; Aghakhani, Ali; Bojko, Barbara; Pawliszyn, Janusz (Wiley, 2017-06-20)Herein we report the development of solid-phase microextraction (SPME) devices designed to perform fast extraction/enrichment of target analytes present in small volumes of complex matrices (i.e. V <= 10 mu L). Micro-sampling ... -
Headspace versus Direct Immersion Solid Phase Microextraction in Complex Matrixes: Investigation of Analyte Behavior in Multicomponent Mixtures
Gionfriddo, Emanuela; Souza-Silva, Erica A.; Pawliszyn, Janusz (American Chemical Society, 2015-07-21)This work aims to investigate the behavior of analytes in complex mixtures and matrixes with the use of solid-phase microextraction (SPME). Various factors that influence analyte uptake such as coating chemistry, extraction ... -
High throughput solid phase microextraction: A new alternative for analysis of cellular lipidome?
Birjandi, Afsoon Pajand; Bojko, Barbara; Ning, Zhibin; Figeys, Daniel; Pawliszyn, Janusz (Elsevier, 2017-02-01)A new SPME method for untargeted lipidomic study of cell line cultures was proposed for the first time. In this study the feasibility to monitor changes in lipid profile after external stimuli was demonstrated and compared ... -
In vivo microsampling to capture the elusive exposome
Bessonneau, Vincent; Ings, Jennifer Sophia; McMaster, Mark; Smith, Richard; Bragg, Leslie M.; Servos, Mark R.; Pawliszyn, Janusz (Nature Publishing Group, 2017-03-07)Loss and/or degradation of small molecules during sampling, sample transportation and storage can adversely impact biological interpretation of metabolomics data. In this study, we performed in vivo sampling using solid-phase ... -
Insights into the Effect of the PDMS-Layer on the Kinetics and Thermodynamics of Analyte Sorption onto the Matrix-Compatible Solid Phase Microextraction Coating
Souza-Silva, Erica A.; Gionfriddo, Emanuela; Alam, Md. Nazmul; Pawliszyn, Janusz (American Chemical Society, 2017-03-07)The currently presented research investigated the performance of matrix compatible PDMS-overcoated fibers (PDMS-DVB/PDMS) as compared to unmodified PDMS/ DVB coatings using aqueous samples and employing a wide range of ... -
Inter-laboratory validation of a thin film microextraction technique for determination of pesticides in surface water samples
Piri-Moghadam, Hamed; Gionfriddo, Emanuela; Rodriguez-Lafuente, Angel; Grandy, Jonathan J.; Lord, Heather L.; Obal, Terry; Pawliszyn, Janusz (Elsevier, 2017-04-29)The primary goal of the present study is the inter-laboratory evaluation of a thin film microextraction (TFME) technique to be used as an alternative approach to liquid-liquid extraction (LLE). Polydimethylsiloxane/ ... -
Introducing a mechanically robust SPME sampler for the on-site sampling and extraction of a wide range of untargeted pollutants in environmental waters
Grandy, Jonathan J.; Lashgari, Maryam; Vander Heide, Harmen; Poole, Justen J.; Pawliszyn, Janusz (Elsevier, 2019-09)The present study introduces a mechanically robust, sealable SPME sampler for the on-site sampling and extraction of a wide range of untargeted pollutants in environmental waters. Spray-coating and dip coating methodologies ... -
Major liver resection, systemic fibrinolytic activity, and the impact of tranexamic acid
Karanicolas, Paul J.; Lin, Yulia; Tarshis, Jordan; Law, Calvin H. L.; Coburn, Natalie G.; Hallet, Julie; Nascimento, Barto; Pawliszyn, Janusz; McCluskey, Stuart A. (Elsevier, 2016-12-01)Background: Hyperfibrinolysis may occur due to systemic inflammation or hepatic injury that occurs during liver resection. Tranexamic acid (TXA) is an antifibrinolytic agent that decreases bleeding in various settings, but ... -
Matrix compatible solid phase microextraction coating, a greener approach to sample preparation in vegetable matrices
Naccarato, Attilio; Pawliszyn, Janusz (Elsevier, 2017-09-01)This work proposes the novel PDMS/DVB/PDMS fiber as a greener strategy for analysis by direct immersion solid phase microextraction (SPME) in vegetables. SPME is an established sample preparation approach that has not yet ... -
Methodical evaluation and improvement of matrix compatible PDMS-overcoated coating for direct immersion solid phase microextraction gas chromatography (DI-SPME-GC)-based applications
Souza-Silva, Erica A.; Gionfriddo, Emanuela; Shirey, Robert; Sidisky, Len; Pawliszyn, Janusz (Elsevier, 2017-05-12)The main quest for the implementation of direct SPME to complex matrices has been the development of matrix compatible coatings that provide sufficient sensitivity towards the target analytes. In this context, we present ... -
Micelle Assisted Thin-Film Solid Phase Microextraction: A New Approach for Determination of Quaternary Ammonium Compounds in Environmental Samples
Boyaci, Ezel; Pawliszyn, Janusz (American Chemical Society, 2014-08-22)Determination of quaternary ammonium compounds (QACs) often is considered to be a challenging undertaking owing to secondary interactions of the analytes’ permanently charged quaternary ammonium head or hydrophobic tail ... -
Micelle assisted thin-film solid phase microextraction: a new approach for determination of quaternary ammonium compounds in environmental samples
Boyaci, Ezel; Pawliszyn, Janusz (ACS, 2014)Determination of quaternary ammonium compounds (QACs) often is considered to be a challenging undertaking owing to secondary interactions of the analytes’ permanently charged quaternary ammonium head or hydrophobic tail ... -
A new and efficient Solid Phase Microextraction approach for analysis of high fat content food samples using a matrix-compatible coating
De Grazia, Selenia; Gionfriddo, Emanuela; Pawliszyn, Janusz (Elsevier, 2017-05-15)The current work presents the optimization of a protocol enabling direct extraction of avocado samples by a new Solid Phase Microextraction matrix compatible coating. In order to further extend the coating life time, ... -
New Generation of Solid-Phase Microextraction Coatings for Complementary Separation Approaches: A Step toward Comprehensive Metabolomics and Multiresidue Analyses in Complex Matrices
Gionfriddo, Emanuela; Boyaci, Ezel; Pawliszyn, Janusz (American Chemical Society, 2017-04-04)In this work, a new generation of solid-phase microextraction (SPME) coatings based on polytetrafluoro-ethylene amorphous fluoroplastics (PTFE AF 2400) as a particle binder is presented. The developed coating was tested ... -
Numerical Modeling of Solid-Phase Microextraction: Binding Matrix Effect on Equilibrium Time
Alam, Md. Nazmul; Ricardez-Sandoval, Luis; Pawliszyn, Janusz (American Chemical Society, 2015-09-07)Solid-phase microextraction (SPME) is a well-known sampling and sample preparation technique used for a wide variety of analytical applications. As there are various complex processes taking place at the time of extraction ...