Browsing Waterloo Research by Author "Edginton, Andrea N."
Now showing items 1-6 of 6
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Data Analysis Protocol for the Development and Evaluation of Population Pharmacokinetic Models for Incorporation Into the Web-Accessible Population Pharmacokinetic Service - Hemophilia (WAPPS-Hemo)
McEneny-King, Alanna; Foster, Gary; Iorio, Alfonso; Edginton, Andrea N. (JMIR Publications, 2016-12-07)Background: Hemophilia is an inherited bleeding disorder caused by a deficiency in a specific clotting factor. This results in spontaneous bleeding episodes and eventual arthropathy. The mainstay of hemophilia treatment ... -
Development of a Web-Accessible Population Pharmacokinetic Service-Hemophilia (WAPPS-Hemo): Study Protocol
Iorio, Alfonso; Keepanasseril, Arun; Foster, Gary; Navarro-Ruan, Tamara; McEneny-King, Alanna; Edginton, Andrea N.; Thabane, Lehana (JMIR Publications, 2016-12-15)Background: Individual pharmacokinetic assessment is a critical component of tailored prophylaxis for hemophilia patients. Population pharmacokinetics allows using individual sparse data, thus simplifying individual ... -
Incorporating Breastfeeding-Related Variability with Physiologically Based Pharmacokinetic Modeling to Predict Infant Exposure to Maternal Medication Through Breast Milk: a Workflow Applied to Lamotrigine
Yeung, Cindy Hoi Ting; Ito, Shinya; Autmizguine, Julie; Edginton, Andrea N. (Springer Nature, 2021-05-17)Current methods to assess risk in infants exposed to maternal medication through breast milk do not specifically account for infants most vulnerable to high drug exposure. A workflow applied to lamotrigine incorporated ... -
Maternal ezetimibe concentrations measured in breast milk and its use in breastfeeding infant exposure predictions
Yeung, Cindy Hoi Ting; Autmizguine, Julie; Dalvi, Pooja; Denoncourt, Audrey; Ito, Shinya; Katz, Pamela; Rahman, Mehzabin; Theoret, Yves; Edginton, Andrea N. (Springer, 2024-01-26)Background: Lactating mothers taking ezetimibe, an antihyperlipidemic agent, may be hesitant to breastfeed despite the known benefit of breastfeeding to both mother and infant. Currently, no data exist on the presence or ... -
Modeling of Body Weight Metrics for Effective and Cost-Efficient Conventional Factor VIII Dosing in Hemophilia A Prophylaxis
McEneny-King, Alanna; Chelle, Pierre; Henrard, Severine; Hermans, Cedric; Iorio, Alfonso; Edginton, Andrea N. (MDPI, 2017-12-01)The total body weight-based dosing strategy currently used in the prophylactic treatment of hemophilia A may not be appropriate for all populations. The assumptions that guide weight-based dosing are not valid in overweight ... -
Physiologically-based pharmacokinetic model for ciprofloxacin in children with complicated urinary tract infection
Balbas-Martinez, Violeta; Michelet, Robin; Edginton, Andrea N.; Meesters, Kevin; Troconiz, Iñaki; Vermeulen, An (Elsevier, 2019-02-01)In a recent multicenter population pharmacokinetic study of ciprofloxacin administered to children suffering from complicated urinary tract infection (cUTI), the apparent volume of distribution (V) and total plasma clearance ...