Browsing Waterloo Research by Author "Ito, Shinya"
Now showing items 1-2 of 2
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Incorporating Breastfeeding-Related Variability with Physiologically Based Pharmacokinetic Modeling to Predict Infant Exposure to Maternal Medication Through Breast Milk: a Workflow Applied to Lamotrigine
Yeung, Cindy Hoi Ting; Ito, Shinya; Autmizguine, Julie; Edginton, Andrea N. (Springer Nature, 2021-05-17)Current methods to assess risk in infants exposed to maternal medication through breast milk do not specifically account for infants most vulnerable to high drug exposure. A workflow applied to lamotrigine incorporated ... -
Maternal ezetimibe concentrations measured in breast milk and its use in breastfeeding infant exposure predictions
Yeung, Cindy Hoi Ting; Autmizguine, Julie; Dalvi, Pooja; Denoncourt, Audrey; Ito, Shinya; Katz, Pamela; Rahman, Mehzabin; Theoret, Yves; Edginton, Andrea N. (Springer, 2024-01-26)Background: Lactating mothers taking ezetimibe, an antihyperlipidemic agent, may be hesitant to breastfeed despite the known benefit of breastfeeding to both mother and infant. Currently, no data exist on the presence or ...