Browsing Waterloo Research by Author "Lee, Ker-Ai"
Now showing items 1-6 of 6
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Classical regression and predictive modeling
Cook, Richard; Lee, Ker-Ai; Lo, Benjamin W.Y.; Macdonald, R. Loch (Elsevier, 2022-05)BACKGROUND: With the advent of personalized and stratified medicine, there has been much discussion about predictive modeling and the role of classical regression in modern medical research. We describe and distinguish the ... -
A copula model for marked point processes
Diao, Liqun; Cook, Richard J.; Lee, Ker-Ai (Springer, 2013)Many chronic diseases feature recurring clinically important events. In addition, however, there often exists a random variable which is realized upon the occurrence of each event reflecting the severity of the event, a ... -
Design of cancer trials based on progression-free survival with intermittent assessment
Zeng, Leilei; Cook, Richard J.; Lee, Ker-Ai (Wiley, 2018-03-26)Therapeutic advances in cancer mean that it is now impractical to performed phase III randomized trials evaluating experimental treatments on the basis of overall survival. As a result, the composite endpoint of progression-free ... -
Inverse Probability Weighted Estimating Equations for Randomized Trials in Transfusion Medicine
Cook, Richard J.; Lee, Ker-Ai; Cuerden, Meaghan; Cotton, Cecilia (Wiley, 2013-03-26)Thrombocytopenia is a condition characterized by extremely low platelet counts, which puts patients at elevated risk of morbidity and mortality because of bleeding. Trials in transfusion medicine are routinely designed ... -
A Multistate Model for Bivariate Interval-Censored Failure Time Data
Cook, Richard J.; Zeng, Leilei; Lee, Ker-Ai (Wiley, 2008-12)Interval-censored life-history data arise when the events of interest are only detectable at periodic assessments. When interest lies in the occurrence of two such events, bivariate-interval censored event time data are ... -
Robust Estimation of Mean Functions and Treatment Effects for Recurrent Events Under Event-Dependent Censoring and Termination: Application to Skeletal Complications in Cancer Metastatic to Bone
Cook, Richard J.; Lakhal-Chaieb, Lajmi; Lee, Ker-Ai; Lawless, Jerald F. (Taylor & Francis, 2009)In clinical trials featuring recurrent clinical events, the definition and estimation of treatment effects involves a number of interesting issues, especially when loss to follow-up may be eventrelated and when terminal ...